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Molecule Parameter List for IP3 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| IP3 participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 25 | 0 | 0 | 0 | 0 | 0 | 0 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2007_ReacDiff3 | 84 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff3, PKC, PLA2,
MAPK, PLA2, Ras, CaM, chain, kinetics, PKC, MAPK, Ras, CaM, kinetics[1],
PKC, PLA2, MAPK, Ras, CaM, kinetics[2], PKC, PLA2, MAPK, Ras, CaM, kinetics[3],
PKC, PLA2, MAPK, Ras, CaM, kinetics[4], PKC, PLA2, MAPK, Ras, CaM, kinetics[5],
PKC, PLA2, MAPK, Ras, MAPK, CaM, kinetics[6], PKC, PLA2, MAPK, Ras,
CaM, kinetics[7], PKC, PLA2, MAPK, Ras, CaM, PKC, kinetics[8], PLA2,
MAPK, Ras, CaM, kinetics[9], PKC, PLA2, MAPK, Ras, CaM, kinetics[10],
PKC, PLA2, MAPK, Ras, CaM, kinetics[11], PKC, PLA2, MAPK, Ras, CaM,
kinetics[12], PKC, PLA2, Ras, CaM, kinetics[13], PKC, PLA2, MAPK,
Ras, CaM, kinetics[14], PKC, PLA2, MAPK, Ras, CaM, kinetics[15],
PKC, PLA2, MAPK, Ras, kinetics[16], CaM, PKC, PLA2, MAPK, Ras, CaM,
kinetics[17], PKC, PLA2, MAPK, Ras, CaM, kinetics[18], PKC, PLA2,
MAPK, Ras, CaM, kinetics[19], PKC, PLA2, MAPK, Ras, CaM, kinetics[20],
PKC, PLA2, MAPK, Ras, CaM, kinetics[21], PKC, PLA2, MAPK, Ras, CaM,
kinetics[22], PKC, PLA2, MAPK, Ras, CaM, kinetics[23], PKC, PLA2,
MAPK, Ras, CaM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. |
IP3 acting as a Molecule in Ajay_Bhalla_2007_ReacDiff3 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics
Pathway No. : 926 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[1]
Pathway No. : 931 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[2]
Pathway No. : 937 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[3]
Pathway No. : 943 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[4]
Pathway No. : 949 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[5]
Pathway No. : 955 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[6]
Pathway No. : 962 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[7]
Pathway No. : 968 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[8]
Pathway No. : 975 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[9]
Pathway No. : 980 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[10]
Pathway No. : 986 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[11]
Pathway No. : 992 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[12]
Pathway No. : 998 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[13]
Pathway No. : 1003 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[14]
Pathway No. : 1009 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[15]
Pathway No. : 1015 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[16]
Pathway No. : 1020 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[17]
Pathway No. : 1027 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[18]
Pathway No. : 1033 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[19]
Pathway No. : 1039 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[20]
Pathway No. : 1045 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[21]
Pathway No. : 1051 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[22]
Pathway No. : 1057 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. | | IP3 | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[23]
Pathway No. : 1063 | 0.73 | 125.7 | Yes | | Peak IP3 is perhaps 15 uM, basal <= 0.2 uM. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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