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Molecule Parameter List for IP3.IP3R | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP3.IP3R acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP3.IP3R | Osc_Ca_
IP3metabolism
Accession No. : 24 | Othmer-Tang-mode
l
Pathway No. : 133 | 0 | 1000 | No | | IP3 Receptor with IP3 bound. This state does not conduct Ca as per Tang et al, Biophys J 70; 1996 |
IP3.IP3R acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | bind_act_Ca | Osc_Ca_
IP3metabolism
Accession No. : 24 | Othmer-Tang-mode
l
Pathway No. : 133 | 15
(uM^-1 s^-1) | 1.65
(s^-1) | Kd(bf) = 0.11(uM) | - | Substrate
Ca
IP3.IP3R
Product
Ca.IP3.IP3R
| | from the O-T model in Tang et al, Biophys J 70, 1996 |
IP3.IP3R acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | bind_IP3 | Osc_Ca_
IP3metabolism
Accession No. : 24 | Othmer-Tang-mode
l
Pathway No. : 133 | 12
(uM^-1 s^-1) | 8
(s^-1) | Kd(bf) = 0.6667(uM) | - | Substrate
IP3
IP3R
Product
IP3.IP3R
| | from the O-T model in Tang et al, Biophys J 70, 1996 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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