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Molecule Parameter List for Ca-ext

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
Ca-ext participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    Ca-ext acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    Ca-ext
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaRegulation
    Pathway No. : 132
    4000100000Yes
    Extracell Ca conc = 4 mM Extracell vol assumed 100 X cell vol. It is anyway kept buffered for the purposes of the model, so the concentration won't change.

    Ca-ext acting as a Product of an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    CaEPump  /
    Ca-pump-out
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • CaRegulation
    Pathway No. : 132
    0.08999772004explicit E-S complexSubstrate
    Ca

    Product
    Ca-ext
    Both affinity and Vmax of the Ca-pump are higher than those used in the model that generates non-oscillatory Ca dynamics. Km has been decreased from 0.2 to 0.09 uM and Vmax increased from 72 to 200. The parameters are constrained by the need to generate Ca oscillations by the Othmer-Tang model.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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