|
Name | Pathway Name / Pathway No. | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of |
1 | AC1-CaM | AC
Pathway No. 31 | Network | 0 | 1000 | No | - |
2 | AC1 | AC
Pathway No. 31 | Network | 0.02 | 1000 | No | - |
3 | AC2* | AC
Pathway No. 31 | Network | 0 | 1000 | No | - |
4 | AC2-Gs | AC
Pathway No. 31 | Network | 0 | 1000 | No | - |
5 | AC2 | AC
Pathway No. 31 | Network | 0.015 | 1000 | No | - |
6 | AC1-Gs | AC
Pathway No. 31 | Network | 0 | 1000 | No | - |
7 | AMP | AC
Pathway No. 31 | Network | 325490 | 0.0016667 | No | - |
8 | AC2*-Gs | AC
Pathway No. 31 | Network | 0 | 1000 | No | - |
9 | cAMP-PDE | AC
Pathway No. 31 | Network | 0.45 | 1000 | No | - |
10 | cAMP-PDE* | AC
Pathway No. 31 | Network | 0 | 1000 | No | - |
11 | PDE1 | AC
Pathway No. 31 | Network | 2 | 1000 | No | - |
12 | CaM.PDE1 | AC
Pathway No. 31 | Network | 0 | 1000 | No | - |
13 | ATP | AC
Pathway No. 31 | Network | 5000 | 1000 | Yes | - |
14 | R2C2 | PKA
Pathway No. 30 | Network | 0.5 | 1000 | No | - |
| PKA: Protein kinase activated by cAMP.
R2C2 complex consists of 2 catalytic (C) subunits, and the R-dimer. There are two types of cAMP binding sites termed A and B according to the rate with which they exchange bound labelled nucleotide.
Dagfinn Ogreid and Stein Ove Doskeland (1981) Int.J.Biochem. 13(1):1-19
Physiological concentration of PKA = 0.59 uM (cardiac myocyte)
Jeffrey J. Saucerman et al (2003) J.Biol.Chem. 278(48):47997-48003 |
15 | R2C2-cAMP | PKA
Pathway No. 30 | Network | 0 | 1000 | No | - |
| R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to site B1 on the regulatory subunit. |
16 | R2C2-cAMP2 | PKA
Pathway No. 30 | Network | 0 | 1000 | No | - |
| R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to each of the B sites on the regulatory subunit. |
17 | R2C2-cAMP3 | PKA
Pathway No. 30 | Network | 0 | 1000 | No | - |
| R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 3 cAMP molecules bound to it. |
18 | R2C2-cAMP4 | PKA
Pathway No. 30 | Network | 0 | 1000 | No | - |
| R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 4 cAMP molecules bound to it. All the regulatory subunits now have cAMP bound. This state is ready to dissociate and to release the catalytic subunit. |
19 | R2C-cAMP4 | PKA
Pathway No. 30 | Network | 0 | 1000 | No | - |
| R-dimer bound to 4 cAMP molecules. |
20 | R2-cAMP4 | PKA
Pathway No. 30 | Network | 0 | 1000 | No | - |