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Accession Type:
Network
Osc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
IP3-3K
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
 Molecule
 Reaction
IHP-system
1345_dephos
CaRegulation
Othmer-Tang-mode
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Molecule List for pathway IP4-system (Pathway Number 167)

 Name Initial Conc. (uM) Volume (fL) Buffered
1IP3(134)01000No
    Inositol (134)trisphosphate
2IP3-56Kcmplx01000No
    enzyme substrate complex of IP3 56-K and Ins(134)P3. Complex exclusively modeled as reaction generates ratio of products, and because 5-kinase is reversible due to large Ins(1345)P4 backflux
3IP3-56K_IP4-1K1.6321000No
    Combined Ins(134)P3 5,6-kinase and Ins(3456)P4 1-kinase: from Yang and Shears, Biochem J 2000, 351: 551-555. Conc from Wilson and Majerus, JBC 271(20); 1996: 11904-10 5,6K Reaction products Ins(1346)P4 and Ins(1345)P4 are generated in a ratio of 2.3-5 : 1 Enzyme inhibition by products, as depicted in previous versions of the model, removed because it is now shown that enzyme is multi-tasking and reversible with respect to these products: Ho et al, Curr Biol 2002, 12: 1-20. This non M-M ability has been incorporated. But cycling to Ins(346)P3 by this enzyme not included because rest of Ins(346)P3 network biology is unknown in mammals.
4IP4(1346)11000No
    Inositol (1346)tetrakisphosphate
5IP4(1456)11000No
    Inositol(1456)tetrakisphosphate
6IP4(3456)1.41000No
    Inositol (3456)tetrakisphosphate basal levels ~ 1.4uM
7IP4-3K0.00481000No
    Ins(1456)P4 3kinase from Stephens et al, Biochem J 249; 1988: 283-92
8ip4_1k_cmplx01000No
    Enzyme complex exclusively modeled to accomodate reversible kinetics as opposed to M-M kinetics. Enzyme reversibility ascertained from dG calculations at -10 kJ/mol that yield a significant back flux from IP5. Also IP4-1K is experimentally reversible: Ho et al, Curr Biol, Mar 2002, 12: 1-20
9ip4_3k_cmplx01000No
    Enzyme complex exclusively modeled to include reversible kinetics, as the back flux is significant for dG = -10 kJ/mol
10IP5(13456)53.99921000No
    Inositol(13456)pentakisphosphate Conc from Voglmaier et al, PNAS 93; 1996


Pathway Details  Molecule List  Enzyme List   Reaction List  


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