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Accession Type:
Network
Ajay_Bhalla_
2004_Feedback_
Tuning
Shared_Object_
Ajay_Bhalla_
2004_Feedback_
Tuning
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
 Molecule
 Reaction
PLC_g
CaMKII
CaM
PP1
PP2B
PKA
AC

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Molecule List for pathway Sos (Pathway Number 355)

 Name Initial Conc. (uM) Volume (fL) Buffered
1Grb211.5No
    There is probably a lot of it in the cell: it is also known as Ash (abundant src homology protein I think). Also Waters et al JBC 271:30 18224 1996 say that only a small fraction of cellular Grb is precipitated out when SoS is precipitated. As most of the Sos seems to be associated with Grb2, it would seem like there is a lot of the latter. Say 1 uM. I haven't been able to find a decent....
2Sos0.11.5No
    I have tried using low (0.02 uM) initial concs, but these give a very flat response to EGF stim although the overall activation of Ras is not too bad. I am reverting to 0.1 because we expect a sharp initial response, followed by a decline. Sep 17 1997: The transient activation curve looks better with [Sos] = 0.05. Apr 26 1998: Some error there, it is better where it was at 0.1
3Sos*01.5No
4Sos*.Grb201.5No
5Sos.Grb201.5No


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