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Reaction List for pathway HomoArginine (Pathway Number 309) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
Homoarginine_
binding | kf
(uM^-1 s^-1) | 250000
(s^-1) | Kd(bf) = 10000(uM) | - | Homoarginine
Im-nNOS
| Im-nNOS-Homoargi
nine
| | | Binding of Homoarginine to Imidazole bound rat brainneuronal Nitric Oxide Synthase.Only Kd is known, Kf and Kb need to be approximatedaccordingly to match kinetic profiles. Due to lack of appropriate graphs the choice of Kf and Kb here is arbitrary and matches only the Kd. Kd = 10mM = 10000uM, Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. | | 2 |
Imidazole_
release | kf
(s^-1) | 0.2
(uM^-1 s^-1) | Kd(cb) = 0.0048(uM) | - | Im-nNOS-Homoargi
nine
| nNOS-Homoarginin
e
Imidazole
| | | Release of Imidazole from complex of Homoarginine and Imidazole bound rat brainneuronal Nitric Oxide Synthase. Abu-Soud HM et al. Biochemistry. 1999 Sep 21;38(38):12446-51. |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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