 |  |  CaRegulation |
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Reaction List for pathway Othmer-Tang-model (Pathway Number 171) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
actIP3R | kf
(uM^-2 s^-1) | 5
(s^-1) | Keq = 0.005(uM) | - | mirror_
Ca.IP3.IP3R
mirror_
Ca.IP3.IP3R
mirror_
Ca.IP3.IP3R
| activeIP3R
| | | Rate set so that almost all Ca.IP3.IP3R complex (formed by Ca and IP3 binding to the IP3R) becomes the active Ca conducting channel | | 2 |
bind_act_Ca | kf
(uM^-1 s^-1) | 1.65
(s^-1) | Kd(bf) = 0.11(uM) | - | IP3.IP3R
Ca
| Ca.IP3.IP3R
| | | from the O-T model in Tang et al, Biophys J 70, 1996 | | 3 |
bind_inact_Ca | kf
(uM^-1 s^-1) | 0.21
(s^-1) | Kd(bf) = 0.1167(uM) | - | Ca.IP3.IP3R
Ca
| Ca2.IP3.IP3R
| | | from the O-T model in Tang et al, Biophys J 70, 1996 | | 4 |
bind_IP3 | kf
(uM^-1 s^-1) | 8
(s^-1) | Kd(bf) = 0.6667(uM) | - | IP3R
IP3
| IP3.IP3R
| | | from the O-T model in Tang et al, Biophys J 70, 1996 |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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