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Molecule Parameter List for MAPKK-ser

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPKK-ser participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002200

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

MAPKK-ser acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
MAPKK-serfig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
01000No

MAPKK-ser acting as a Substrate for an Enzyme in  
fig2_egfr Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1Raf-GTP-Ras*  /
Raf-GTP-Ras*.2
fig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
0.1590910.1054explicit E-S complexSubstrate
MAPKK-ser

Product
MAPKK*
2PPhosphatase2A  /
MAPKK-deph-ser
fig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 15.656664.16667explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK

    MAPKK-ser acting as a Product of an Enzyme in  
    fig2_egfr Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1Raf-GTP-Ras*  /
    Raf-GTP-Ras*.1
    fig2_egfr
    Accession No. : 1
    MAPK
    Pathway No. : 6
    0.1590910.1054explicit E-S complexSubstrate
    MAPKK

    Product
    MAPKK-ser
    2PPhosphatase2A  /
    MAPKK-deph
    fig2_egfr
    Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 15.656664.16667explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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