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Molecule Parameter List for AMP | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AMP participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 4 | 0 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| fig3_CaMKII | 2 | Network | Shared_Object_fig3_CaMKII, CaMKII, CaM, PP1, PP2B, PKA, AC |
| This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse. Demonstration script files for generating the figures in the paper, including figure 3, are available here. | |||
AMP acting as a Molecule in fig3_CaMKII Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| AMP | fig3_CaMKII Accession No. : 2 | AC Pathway No. : 18 | 325490 | 0.0016667 | No | |
AMP acting as a Product of an Enzyme in fig3_CaMKII Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | |
| 1 | cAMP-PDE / PDE | fig3_CaMKII Accession No. : 2 | AC Pathway No. : 18 | 19.8413 | 10 | 4 | explicit E-S complex | Substrate cAMP Product AMP |
| 2 | cAMP-PDE* / PDE* | fig3_CaMKII Accession No. : 2 | AC Pathway No. : 18 | 19.8413 | 20 | 4 | explicit E-S complex | Substrate cAMP Product AMP |
| 3 | PDE1 / PDE1 | fig3_CaMKII Accession No. : 2 | AC Pathway No. : 18 | 39.7 | 1.667 | 4.0012 | explicit E-S complex | Substrate cAMP Product AMP |
| 4 | CaM.PDE1 / CaM.PDE1 | fig3_CaMKII Accession No. : 2 | AC Pathway No. : 18 | 39.6825 | 10 | 4 | explicit E-S complex | Substrate cAMP Product AMP |