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Molecule Parameter List for CaM(Ca)n-CaNAB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaM(Ca)n-CaNAB* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	3	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig3_CaMKII	2	Network	Shared_Object_fig3_CaMKII, CaMKII, CaM, PP1, PP2B, PKA, AC
This is the model file for figure 3 from Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It is a model of the Ca activation of CaMKII and other CaM-activated enzymes. It includes the regulatory phosphatases PP1 and PP2B (Calcineurin) acting on CaMKII and also includes CaM-activated adenylyl cyclase and PKA in the synapse. Demonstration script files for generating the figures in the paper, including figure 3, are available here.

CaM(Ca)n-CaNAB acting as a Molecule in fig3_CaMKII Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM(Ca)n-CaNAB	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	0	1000	No

CaM(Ca)n-CaNAB acting as a Summed Molecule in fig3_CaMKII Network

	Accession Nane	Pathway Name	Target	Input
1	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	CaM(Ca)n-CaNAB	CaMCa4-CaNAB CaMCa3-CaNAB CaMCa2-CANAB
2	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	tot_CaN-active	CaM(Ca)n-CaNAB CaNAB-Ca4

CaM(Ca)n-CaNAB acting as an Enzyme in fig3_CaMKII Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	CaM(Ca)n-CaNAB / dephosph_ neurogranin	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	10.012	0.67	3.98507	explicit E-S complex	Substrate neurogranin* Product neurogranin
2	CaM(Ca)n-CaNAB / dephosph_inhib1	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	4.97076	0.34	4	explicit E-S complex	Substrate I1* Product I1
3	CaM(Ca)n-CaNAB / dephosph-PP1-I*	fig3_CaMKII Accession No. : 2	Shared_Object_ fig3_CaMKII Pathway No. : 12	4.97076	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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