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Molecule Parameter List for IP4-1K

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP4-1K participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP4-1K acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP4-1K	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.606	1000	No
from Tan et al, JBC 272(4); 1997: 2285-90

IP4-1K acting as an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP4-1K / ip4-1k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.359995	0.598	4	explicit E-S complex	Substrate IP4(3456) Product IP5(13456)
from Tan et al, JBC 272; 1997

IP4-1K acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	ip5-inhib-1k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1 (uM^-1 s^-1)	15 (s^-1)	Kd(bf) = 15(uM)	-	Substrate IP4-1K IP5(13456) Product IP5-1Kcmplx
	from Tan et al, JBC 272; 1997
2	ip3-inhib-1k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate IP3(134) IP4-1K Product IP3-1Kcmplx
	from Tan et al, JBC 272; 1997