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Molecule Parameter List for IP5(13456)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP5(13456) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	2	7	3

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP5(13456) acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP5(13456)	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	53.9992	1000	No
Inositol(13456)pentakisphosphate Conc from Voglmaier et al, PNAS 93; 1996

IP5(13456) acting as a Substrate for an Enzyme in  NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP6_K2  / ip5_k2	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	8.4	0.0572	4	explicit E-S complex	Substrate IP5(13456) Product PP-IP4
	from Saiardi et al, JBC 275(32); 2000: 24686-92
2	IP6-K  / ip5_k1	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	6.69999	0.234	4	explicit E-S complex	Substrate IP5(13456) Product PP-IP4
	from Saiardi et al, JBC 275(32); 2000: 24686-92

IP5(13456) acting as a Product of an Enzyme in  NonOsc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP4-1K  / ip4-1k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.359995	0.598	4	explicit E-S complex	Substrate IP4(3456) Product IP5(13456)
	from Tan et al, JBC 272; 1997
2	IP4-3K  / ip4-3k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.399999	4.3	4	explicit E-S complex	Substrate IP4(1456) Product IP5(13456)
	from Stephens et al, Biochem J 249; 1988

IP5(13456) acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IP5-inhib-5pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	1 (uM^-1 s^-1)	45 (s^-1)	Kd(bf) = 44.9991(uM)	-	Substrate IP5(13456) IP_5pase1 Product IP5-5pase-cmplx
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
2	ip5_3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.0005 (s^-1)	0 (s^-1)	-	-	Substrate IP5(13456) Product IP4(1456)
	Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991
3	ip5-1-pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.0031 (s^-1)	0 (s^-1)	-	-	Substrate IP5(13456) Product IP4(3456)
	most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80
4	ip5-inhib-1k	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	1 (uM^-1 s^-1)	15 (s^-1)	Kd(bf) = 15(uM)	-	Substrate IP4-1K IP5(13456) Product IP5-1Kcmplx
	from Tan et al, JBC 272; 1997
5	ip5-kinase-pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	1 (s^-1)	1.92 (s^-1)	Keq = 1.92(uM)	0.342sec	Substrate IP5(13456) Product IP6
	Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels
6	IP5-dipp-inhib	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	1 (uM^-1 s^-1)	1.6 (s^-1)	Kd(bf) = 1.6(uM)	-	Substrate DIPP1 IP5(13456) Product IP5-DIPPcmplx
	IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998
7	IP5-inhib-3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	1345_dephos Pathway No. : 117	1 (uM^-1 s^-1)	0.06 (s^-1)	Kd(bf) = 0.06(uM)	-	Substrate 1345_3pase IP5(13456) Product IP5-3pase-cmplx
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224

IP5(13456) acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	ip5(13456)_trp	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	1 (s^-1)	0.001 (s^-1)	Not applicable**	-	Substrate IP5(13456)_ER Product IP5(13456)
	Ins(13456)P5 ER-cytosol transport
2	ip4-5K	NonOsc_Ca_ IP3metabolism Accession No. : 23	IP4-system Pathway No. : 115	0.008 (s^-1)	0 (s^-1)	-	-	Substrate IP4(1346) Product IP5(13456)
	rate based on basal levels of Ins(1346)P4
3	dipp_ip6	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	0 (s^-1)	0 (s^-1)	-	-	Substrate PP-IP4 Product IP5(13456)
	rate based on basal levels of PP-InsP4