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Molecule Parameter List for IP6

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP6 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	6	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
NonOsc_Ca_ IP3metabolism	23	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  CaRegulation,   Gq,  PLCbeta,  134_dephos,   145_dephos,  IP4-system,  IHP-system,   1345_dephos
This network models detailed metabolism of Ins(145)P3, integrated with GPCR mediated PLCbeta activation and Ca release by the InsP3 receptor in the neuron. The calcium response is non-oscillatory. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP6 acting as a Molecule in  NonOsc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP6	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	30.0005	1000	No
Inositol hexakisphosphate Conc from Voglmaier et al, PNAS 93; 1996

IP6 acting as a Substrate for an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP6_K2  / ip6_k2	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	2.99999	1.633	4	explicit E-S complex	Substrate IP6 Product PP-IP5
from Saiardi et al, Curr Biol 9; 1999

IP6 acting as a Product of an Enzyme in  NonOsc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
DIPP1  / dipp_ip7	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	0.340006	5.1	4	explicit E-S complex	Substrate PP-IP5 Product IP6
from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of recombinant human protein which is 20-50 fold greater than activity of the purified rat enzyme

IP6 acting as a Substrate in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	ip6_trp	NonOsc_Ca_ IP3metabolism Accession No. : 23	MIPP Pathway No. : 105	0.001 (s^-1)	1 (s^-1)	Not applicable**	-	Substrate IP6 Product IP6_ER
	InsP6 ER-cytosol transport
2	IP_4pase-inact	NonOsc_Ca_ IP3metabolism Accession No. : 23	134_dephos Pathway No. : 113	1 (uM^-1 s^-1)	19 (s^-1)	Kd(bf) = 19(uM)	-	Substrate IP6 IP_4pase Product IP_4pase_inact
	from Norris et al, JBC 269; 1994
3	IP6-inhib-5pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	145_dephos Pathway No. : 114	1 (uM^-1 s^-1)	16 (s^-1)	Kd(bf) = 15.9997(uM)	-	Substrate IP6 IP_5pase1 Product IP6-5pase-inhib
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
4	IP6-dipp-inhib	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	1 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate DIPP1 IP6 Product IP6-DIPPcmplx
	IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998
5	IP6cmplx-on	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	0.0038 (uM^-2 s^-1)	2.376 (s^-1)	-	-	Substrate ATP IP6 IP6-K Product IP6-K-complex
	from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction
6	IP6-inhib-3pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	1345_dephos Pathway No. : 117	1 (uM^-1 s^-1)	0.003 (s^-1)	Kd(bf) = 0.003(uM)	-	Substrate 1345_3pase IP6 Product IP6-inhib-3pase- cmplx
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224

IP6 acting as a Product in a reaction in  NonOsc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
ip5-kinase-pase	NonOsc_Ca_ IP3metabolism Accession No. : 23	IHP-system Pathway No. : 116	1 (s^-1)	1.92 (s^-1)	Keq = 1.92(uM)	0.342sec	Substrate IP5(13456) Product IP6
Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels