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Molecule Parameter List for IP3(134)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP3(134) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	1	3	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP3(134) acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP3(134)	Osc_Ca_ IP3metabolism Accession No. : 24	134_dephos Pathway No. : 127	0	1000	No
Inositol (134)trisphosphate

IP3(134) acting as a Substrate for an Enzyme in  Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP_4pase  / ip3_4pase	Osc_Ca_ IP3metabolism Accession No. : 24	134_dephos Pathway No. : 127	20.0014	20	4	explicit E-S complex	Substrate IP3(134) Product IP2(13)
	Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2
2	IP_1pase  / ip3_1pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	20.0021	4.125	4	explicit E-S complex	Substrate IP3(134) Product IP2(34)
	Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987

IP3(134) acting as a Product of an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP_5pase1  / ip4_5pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	0.80003	0.09	4	explicit E-S complex	Substrate IP4(1345) Product IP3(134)
Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3

IP3(134) acting as a Substrate in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IP3-Kcmplx-on	Osc_Ca_ IP3metabolism Accession No. : 24	IP4-system Pathway No. : 129	3 (uM^-1 s^-1)	0.192 (s^-1)	Kd(bf) = 0.064(uM)	-	Substrate IP3(134) IP3-56K Product IP3-56Kcmplx
	Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from Km and Vmax values provided by Wilson and Majerus, JBC 271; 1996
2	ip3-inhib-1k	Osc_Ca_ IP3metabolism Accession No. : 24	IP4-system Pathway No. : 129	1 (uM^-1 s^-1)	0.2 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate IP3(134) IP4-1K Product IP3-1Kcmplx
	from Tan et al, JBC 272; 1997
3	134-inhib-3pase	Osc_Ca_ IP3metabolism Accession No. : 24	1345_dephos Pathway No. : 131	1 (uM^-1 s^-1)	2 (s^-1)	Kd(bf) = 2(uM)	-	Substrate 1345_3pase IP3(134) Product IP3(134)-3pase-c mplx
	from Hoer et al, Biochem J 270; 1990