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Molecule Parameter List for IP2(13) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_ IP3metabolism | 24 | Network | MIPP, CaMKII, CaM, PKC, IP3-3K, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos, CaRegulation, Othmer-Tang-model | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP2(13) acting as a Molecule in Osc_Ca_IP3metabolism Network
Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | IP2(13) | Osc_Ca_ IP3metabolism Accession No. : 24 | 134_dephos Pathway No. : 127 | 0 | 1000 | No | Inositol (13)bisphosphate according to Batty et al (Biochem J 258(1); 1989: 23-32) Ins(13)P2 forms 22% of all InsP2 in cerebral cortex slices. Our simulations generate similar basal levels |
IP2(13) acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | 1 | IP2_3pase2 / ip2_3pase2 | Osc_Ca_ IP3metabolism Accession No. : 24 | 134_dephos Pathway No. : 127 | 3.70001 | 39.2 | 4 | explicit E-S complex | Substrate IP2(13)
Product IP1(1)
| | from Caldwell et al, JBC 266; 1991 | 2 | IP2_3pase1 / ip2_3pase1 | Osc_Ca_ IP3metabolism Accession No. : 24 | 134_dephos Pathway No. : 127 | 0.799992 | 117.33 | 4 | explicit E-S complex | Substrate IP2(13)
Product IP1(1)
| | from Caldwell et al, JBC 266; 1991 enzyme activity was assayed for the monomeric form of the enzyme |
IP2(13) acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP_4pase / ip3_4pase | Osc_Ca_ IP3metabolism Accession No. : 24 | 134_dephos Pathway No. : 127 | 20.0014 | 20 | 4 | explicit E-S complex | Substrate IP3(134)
Product IP2(13)
| Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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