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Molecule Parameter List for IP2(13)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
IP2(13) participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Osc_Ca_
    IP3metabolism
  • 24Network
    MIPP CaMKII CaM 
    PKC IP3-3K Gq 
    PLCbeta 134_dephos 145_dephos 
    IP4-system IHP-system 1345_dephos 
    CaRegulation Othmer-Tang-model 
    This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

    IP2(13) acting as a Molecule in  
    Osc_Ca_IP3metabolism Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    IP2(13)
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 134_dephos
    Pathway No. : 127
    01000No
    Inositol (13)bisphosphate according to Batty et al (Biochem J 258(1); 1989: 23-32) Ins(13)P2 forms 22% of all InsP2 in cerebral cortex slices. Our simulations generate similar basal levels

    IP2(13) acting as a Substrate for an Enzyme in  
    Osc_Ca_IP3metabolism Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1IP2_3pase2  /
    ip2_3pase2
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 134_dephos
    Pathway No. : 127
    3.7000139.24explicit E-S complexSubstrate
    IP2(13)

    Product
    IP1(1)
        from Caldwell et al, JBC 266; 1991
    2IP2_3pase1  /
    ip2_3pase1
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 134_dephos
    Pathway No. : 127
    0.799992117.334explicit E-S complexSubstrate
    IP2(13)

    Product
    IP1(1)
        from Caldwell et al, JBC 266; 1991 enzyme activity was assayed for the monomeric form of the enzyme

    IP2(13) acting as a Product of an Enzyme in  
    Osc_Ca_IP3metabolism Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    IP_4pase  /
    ip3_4pase
  • Osc_Ca_
    IP3metabolism

    Accession No. : 24
  • 134_dephos
    Pathway No. : 127
    20.0014204explicit E-S complexSubstrate
    IP3(134)

    Product
    IP2(13)
    Ins(134)P3 4-phosphatase activity of InsP 4-phosphatase from Norris et al, JBC 269; 1994. Vmax reduced from 55/sec to 20/sec to maintain relative levels of Ins(134)P3 and Ins(13)P2



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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