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Molecule Parameter List for IP_5pase1

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*IP_5pase1* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	0	0	2	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos, CaRegulation, Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP_5pase1 acting as a Molecule in Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP_5pase1	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	12.346	1000	No
from Hansen et al, JBC 262(36); Dec 25 1987: 17319-26 InsP 5phosphatase1 has two 5-phosphatase activities: against Ins(145)P3 and Ins(1345)P4 respectively

IP_5pase1 acting as an Enzyme in Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP_5pase1 / ip3_5pase1	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	3.00001	1.1	4	explicit E-S complex	Substrate IP3(145) Product IP2(14)
	Ins(145)P3 5-phosphatase activity of InsP-5-phosphatase from Hansen et al, JBC 262; 1987
2	IP_5pase1 / ip4_5pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	0.80003	0.09	4	explicit E-S complex	Substrate IP4(1345) Product IP3(134)
	Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3

IP_5pase1 acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IP5-inhib-5pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	1 (uM^-1 s^-1)	45 (s^-1)	Kd(bf) = 44.9991(uM)	-	Substrate IP5(13456) IP_5pase1 Product IP5-5pase-cmplx
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
2	IP6-inhib-5pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	1 (uM^-1 s^-1)	16 (s^-1)	Kd(bf) = 15.9997(uM)	-	Substrate IP6 IP_5pase1 Product IP6-5pase-inhib
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224

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