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Molecule Parameter List for IP1(4)

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP1(4) participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	1	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP1(4) acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP1(4)	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	0	1000	No
Inositol 4-monophosphate

IP1(4) acting as a Substrate for an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP1_pase  / ip1_4pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	190	39.33	4	explicit E-S complex	Substrate IP1(4) Product inositol
Ins(4)P1 4-phsophatase from Gee et al, BiochemJ 249; 1988

IP1(4) acting as a Product of an Enzyme in  Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
IP_1pase  / ip2_1pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	5.00005	2	4	explicit E-S complex	Substrate IP2(14) Product IP1(4)
from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)