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Molecule Parameter List for MAPKK*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

MAPKK* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	1	1	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig4_synapse	3	Network	Shared_Object_fig4_synapse,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here.

MAPKK* acting as a Molecule in  fig4_synapse Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
MAPKK*	fig4_synapse Accession No. : 3	MAPK Pathway No. : 24	0	1000	No

MAPKK* acting as an Enzyme in  fig4_synapse Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	MAPKK* / MAPKKtyr	fig4_synapse Accession No. : 3	MAPK Pathway No. : 24	0.0462963	0.15	4	explicit E-S complex	Substrate MAPK Product MAPK-tyr
2	MAPKK* / MAPKKthr	fig4_synapse Accession No. : 3	MAPK Pathway No. : 24	0.0462963	0.15	4	explicit E-S complex	Substrate MAPK-tyr Product MAPK*

MAPKK* acting as a Substrate for an Enzyme in  fig4_synapse Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PPhosphatase2A  / MAPKK-deph	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	15.6566	6	4.16667	explicit E-S complex	Substrate MAPKK* Product MAPKK-ser

MAPKK* acting as a Product of an Enzyme in  fig4_synapse Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
Raf-GTP-Ras*  / Raf-GTP-Ras*.2	fig4_synapse Accession No. : 3	MAPK Pathway No. : 24	0.159091	0.105	4	explicit E-S complex	Substrate MAPKK-ser Product MAPKK*