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Molecule Parameter List for Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

Ca participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	10	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig4_synapse	3	Network	Shared_Object_fig4_synapse, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, CaMKII, CaM, PP1, PP2B, PKA, AC
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here.

Ca acting as a Molecule in fig4_synapse Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Ca	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	0.08	1000	No

Ca acting as a Substrate in a reaction in fig4_synapse Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PKC-act-by-Ca	fig4_synapse Accession No. : 3	PKC Pathway No. : 20	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
2	PLA2-Ca-act	fig4_synapse Accession No. : 3	PLA2 Pathway No. : 21	1 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate Ca PLA2-cytosolic Product PLA2-Ca*
3	PLA2*-Ca-act	fig4_synapse Accession No. : 3	PLA2 Pathway No. : 21	6 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0167(uM)	-	Substrate Ca PLA2* Product PLA2*-Ca
4	Act-PLC-Ca	fig4_synapse Accession No. : 3	PLCbeta Pathway No. : 22	3 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.3333(uM)	-	Substrate Ca PLC Product PLC-Ca
5	PLC-Gq-bind-Ca	fig4_synapse Accession No. : 3	PLCbeta Pathway No. : 22	30 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.0333(uM)	-	Substrate Ca PLC-Gq Product PLC-Ca-Gq
6	CaM-TR2-bind-Ca	fig4_synapse Accession No. : 3	CaM Pathway No. : 27	72 (uM^-2 s^-1)	72 (s^-1)	Kd(af) = 1(uM)	-	Substrate Ca Ca CaM Product CaM-TR2-Ca2
7	CaM-TR2-Ca2-bind -Ca	fig4_synapse Accession No. : 3	CaM Pathway No. : 27	3.6 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 2.7778(uM)	-	Substrate Ca CaM-TR2-Ca2 Product CaM-Ca3
8	CaM-Ca3-bind-Ca	fig4_synapse Accession No. : 3	CaM Pathway No. : 27	0.465 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 21.5054(uM)	-	Substrate Ca CaM-Ca3 Product CaM-Ca4
9	Ca-bind-CaNAB-Ca 2	fig4_synapse Accession No. : 3	PP2B Pathway No. : 29	3.6 (uM^-2 s^-1)	1 (s^-1)	Kd(af) = 0.527(uM)	-	Substrate Ca Ca CaNAB-Ca2 Product CaNAB-Ca4
10	Ca-bind-CaNAB	fig4_synapse Accession No. : 3	PP2B Pathway No. : 29	10008 (uM^-2 s^-1)	1 (s^-1)	Kd(af) = 0.01(uM)	-	Substrate Ca Ca CaNAB Product CaNAB-Ca2

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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