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Molecule Parameter List for CaM(Ca)n-CaNAB

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaM(Ca)n-CaNAB* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	3	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig4_synapse	3	Network	Shared_Object_fig4_synapse, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, CaMKII, CaM, PP1, PP2B, PKA, AC
This is the composite model of 4 kinases: PKC, MAPK, PKA and CaMKII and numerous regulatory pathways involved in synaptic signaling. From Bhalla US and Iyengar R. Science (1999) 283(5400):381-7.This model comes from figure 4 of that paper. Demonstration script files for generating the figures in the paper, including figure 4, are available here.

CaM(Ca)n-CaNAB acting as a Molecule in fig4_synapse Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM(Ca)n-CaNAB	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	0	1000	No

CaM(Ca)n-CaNAB acting as a Summed Molecule in fig4_synapse Network

	Accession Nane	Pathway Name	Target	Input
1	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	CaM(Ca)n-CaNAB	CaMCa4-CaNAB CaMCa3-CaNAB CaMCa2-CANAB
2	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	CaN-active	CaM(Ca)n-CaNAB CaNAB-Ca4

CaM(Ca)n-CaNAB acting as an Enzyme in fig4_synapse Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	CaM(Ca)n-CaNAB / dephosph_ neurogranin	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	10.012	0.67	3.98507	explicit E-S complex	Substrate neurogranin* Product neurogranin
2	CaM(Ca)n-CaNAB / dephosph_inhib1	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	4.97076	0.34	4	explicit E-S complex	Substrate I1* Product I1
3	CaM(Ca)n-CaNAB / dephosph-PP1-I*	fig4_synapse Accession No. : 3	Shared_Object_ fig4_synapse Pathway No. : 19	4.97076	0.34	4	explicit E-S complex	Substrate PP1-I1* Product PP1-I1

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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