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Molecule Parameter List for IP3_3K*1 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP3_3K*1 acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP3_3K*1 | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP3-3K
Pathway No. : 162 | 0 | 1000 | No | | Sim et al; JBC 265(18) June 25; 1990: pp 10367-10372 Phos. at 2 major sites = Ser109 & Ser 175; but there is a possibility that inactivation is due to combined effect of multiple phosphorylations activity suppressed by 75% |
IP3_3K*1 acting as an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP3_3K*1 /
ip3-3k*1
| Osc_Ca_
IP3metabolism
Accession No. : 32 | IP3-3K
Pathway No. : 162 | 1.40004 | 0.76187 | 4.00003 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | from Sim et al, JBC 265; 1990 |
IP3_3K*1 acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PKC-active /
PKC-phos | Osc_Ca_
IP3metabolism
Accession No. : 32 | PKC
Pathway No. : 161 | 30.0008 | 4 | 4 | explicit E-S complex | Substrate
IP3_3K
Product
IP3_3K*1
| | rates referred from standard PKC phosphorylation rates |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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