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Molecule Parameter List for IP4(1456) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP4(1456) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP4(1456) | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 1 | 1000 | No | | Inositol(1456)tetrakisphosphate |
IP4(1456) acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | ip4-6pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 0.013
(s^-1) | 0
(s^-1) | - | - | Substrate
IP4(1456)
Product
IP3(145)
| | | this step is essential to maintain flux around the network, rate adjusted accordingly | | 2 | ip4-3k-on | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 53.7501
(uM^-1 s^-1) | 17.2
(s^-1) | Kd(bf) = 0.32(uM) | - | Substrate
IP4(1456)
IP4-3K
Product
ip4_3k_cmplx
| | | Rates derived from Km for enzyme: Stephens et al, Biochem J 249; 1988. |
IP4(1456) acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | ip4(1456)_trp | Osc_Ca_
IP3metabolism
Accession No. : 32 | MIPP
Pathway No. : 158 | 1
(s^-1) | 0.001
(s^-1) | Not applicable** | - | Substrate
IP4(1456)_ER
Product
IP4(1456)
| | | Ins(1456)P4 ER-cytosol transport | | 2 | ip5_3pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | IP4-system
Pathway No. : 167 | 0.0003
(s^-1) | 0
(s^-1) | - | - | Substrate
IP5(13456)
Product
IP4(1456)
| | | Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991 Backflux from the reversible InsP4 3-kinase is not sufficient to maintain Ins(1456)P4 levels. Hence this reaction is necessary. This reaction also maintains the flux in the network. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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