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Molecule Parameter List for 1345_3pase

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

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Statistics

*1345_3pase* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	5	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	32	Network	MIPP, CaMKII, CaM, PKC, IP3-3K, Gq, PLCbeta, 134_dephos, 145_dephos, IP4-system, IHP-system, 1345_dephos, CaRegulation, Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

1345_3pase acting as a Molecule in Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
1345_3pase	Osc_Ca_ IP3metabolism Accession No. : 32	1345_dephos Pathway No. : 169	0.1	1000	No
from Hoer et al, BiochemJ 270; 1990: 715-719

1345_3pase acting as an Enzyme in Osc_Ca_IP3metabolism Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1345_3pase / ip4_3pase	Osc_Ca_ IP3metabolism Accession No. : 32	1345_dephos Pathway No. : 169	0.400007	0.0012	4	explicit E-S complex	Substrate IP4(1345) Product IP3(145)
Ins(1345)P4 3-phosphatase from Nogimori et al, JBC 266; 1991

1345_3pase acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	IP5-inhib-3pase	Osc_Ca_ IP3metabolism Accession No. : 32	1345_dephos Pathway No. : 169	1 (uM^-1 s^-1)	0.06 (s^-1)	Kd(bf) = 0.06(uM)	-	Substrate 1345_3pase IP5(13456) Product IP5-3pase-cmplx
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
2	IP6-inhib-3pase	Osc_Ca_ IP3metabolism Accession No. : 32	1345_dephos Pathway No. : 169	1 (uM^-1 s^-1)	0.003 (s^-1)	Kd(bf) = 0.003(uM)	-	Substrate 1345_3pase IP6 Product IP6-inhib-3pase- cmplx
	from Hoer and Oberdisse, Biochem J 278; 1991: 219-224
3	145-inhib-3pase	Osc_Ca_ IP3metabolism Accession No. : 32	1345_dephos Pathway No. : 169	1 (uM^-1 s^-1)	1.75 (s^-1)	Kd(bf) = 1.75(uM)	-	Substrate 1345_3pase IP3(145) Product IP3(145)-3pase-c mplx
	from Hoer et al, Biochem J 270; 1990
4	IP4-inhib-3pase	Osc_Ca_ IP3metabolism Accession No. : 32	1345_dephos Pathway No. : 169	1 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.5(uM)	-	Substrate 1345_3pase IP4(3456) Product IP4-3pase-cmplx
	from Hoer et al, Biochem J 270; 1990
5	134-inhib-3pase	Osc_Ca_ IP3metabolism Accession No. : 32	1345_dephos Pathway No. : 169	1 (uM^-1 s^-1)	2 (s^-1)	Kd(bf) = 2(uM)	-	Substrate 1345_3pase IP3(134) Product IP3(134)-3pase-c mplx
	from Hoer et al, Biochem J 270; 1990

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