| |
Reaction
Name | Pathway Name /
Pathway No. | Kf | Kb | Kd | tau | Reagents |
| 1 | bind_inact_Ca | Othmer-Tang-mode
l
Pathway No. 171 | 1.8001
(uM^-1 s^-1) | 0.21
(s^-1) | Kd(bf) = 0.1167(uM) | - | Substrate:
Ca.IP3.IP3R
Ca
Products:
Ca2.IP3.IP3R
|
| from the O-T model in Tang et al, Biophys J 70, 1996 | | 2 | bind_act_Ca | Othmer-Tang-mode
l
Pathway No. 171 | 15
(uM^-1 s^-1) | 1.65
(s^-1) | Kd(bf) = 0.11(uM) | - | Substrate:
IP3.IP3R
Ca
Products:
Ca.IP3.IP3R
|
| from the O-T model in Tang et al, Biophys J 70, 1996 | | 3 | bind_IP3 | Othmer-Tang-mode
l
Pathway No. 171 | 12
(uM^-1 s^-1) | 8
(s^-1) | Kd(bf) = 0.6667(uM) | - | Substrate:
IP3R
IP3
Products:
IP3.IP3R
|
| from the O-T model in Tang et al, Biophys J 70, 1996 | | 4 | actIP3R | Othmer-Tang-mode
l
Pathway No. 171 | 1000.01
(uM^-2 s^-1) | 5
(s^-1) | Keq = 0.005(uM) | - | Substrate:
mirror_
Ca.IP3.IP3R
mirror_
Ca.IP3.IP3R
mirror_
Ca.IP3.IP3R
Products:
activeIP3R
|
| Rate set so that almost all Ca.IP3.IP3R complex (formed by Ca and IP3 binding to the IP3R) becomes the active Ca conducting channel | | 5 | inactivate_cap_
Ca | CaRegulation
Pathway No. 170 | 0
(#^-2 s^-1) | 10
(s^-1) | Not applicable** | - | Substrate:
Ca-sequester
Ca-sequester
capacitive_Ca_
entry*
Products:
inact_cap_entry
|
| For non-oscillatory Ca dynamics Kd was set at 3 uM. This did not allow for Ca oscillations characteristic of the Othmer-Tang model. The rates here are constrained solely by the need to generate Othmer-Tang type Ca oscillations. | | 6 | Ca5-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Calseq
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Products:
Ca5-Cal
|
| There are actually 5 Ca-sequester substrates for this reaction, along with one Calseq. Due to system limitations only four are entered. | | 7 | Ca10-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Ca5-Cal
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Products:
Ca10-Cal
|
| There are actually 5 Ca-sequester substrates for this reaction, along with Ca5-Cal. Due to system limitations only four are entered. | | 8 | Ca15-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Ca10-Cal
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Products:
Ca15-Cal
|
| There are actually 5 Ca-sequester substrates for this reaction, along with Ca10-Cal. Due to system limitations only four are entered. | | 9 | Ca20-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Ca15-Cal
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Products:
Ca20-Cal
|
| There are actually 5 Ca-sequester substrates for this reaction, along with Ca15-Cal. Due to system limitations only four are entered. | | 10 | Ca25-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca20-Cal
Products:
Ca25-Cal
|
| There are actually 5 Ca-sequester substrates for this reaction, along with Ca20-Cal. Due to system limitations only four are entered. | | 11 | Ca35-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca30-Calseq
Products:
Ca35-Calseq
|
| There are actually 5 Ca-sequester substrates for this reaction, along with Ca30-Cal. Due to system limitations only four are entered. | | 12 | Ca40-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca35-Calseq
Products:
Ca40-Cal
|
| There are actually 5 Ca-sequester substrates for this reaction, along with Ca35-Cal. Due to system limitations only four are entered. | | 13 | Ca30-bind-Cal | CaRegulation
Pathway No. 170 | 0.0005
(uM^-5 s^-1) | 1
(s^-1) | - | - | Substrate:
Ca25-Cal
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Ca-sequester
Products:
Ca30-Calseq
|
| There are actually 5 Ca-sequester substrates for this reaction, along with Ca25-Cal. Due to system limitations only four are entered. | | 14 | IP5-inhib-3pase | 1345_dephos
Pathway No. 169 | 1
(uM^-1 s^-1) | 0.06
(s^-1) | Kd(bf) = 0.06(uM) | - | Substrate:
1345_3pase
IP5(13456)
Products:
IP5-3pase-cmplx
|
| from Hoer and Oberdisse, Biochem J 278; 1991: 219-224 | | 15 | IP6-inhib-3pase | 1345_dephos
Pathway No. 169 | 1
(uM^-1 s^-1) | 0.003
(s^-1) | Kd(bf) = 0.003(uM) | - | Substrate:
1345_3pase
IP6
Products:
IP6-inhib-3pase-
cmplx
|
| from Hoer and Oberdisse, Biochem J 278; 1991: 219-224 | | 16 | 145-inhib-3pase | 1345_dephos
Pathway No. 169 | 1
(uM^-1 s^-1) | 1.75
(s^-1) | Kd(bf) = 1.75(uM) | - | Substrate:
1345_3pase
IP3(145)
Products:
IP3(145)-3pase-c
mplx
|
| from Hoer et al, Biochem J 270; 1990 | | 17 | IP4-inhib-3pase | 1345_dephos
Pathway No. 169 | 1
(uM^-1 s^-1) | 0.5
(s^-1) | Kd(bf) = 0.5(uM) | - | Substrate:
IP4(3456)
1345_3pase
Products:
IP4-3pase-cmplx
|
| from Hoer et al, Biochem J 270; 1990 | | 18 | 134-inhib-3pase | 1345_dephos
Pathway No. 169 | 1
(uM^-1 s^-1) | 2
(s^-1) | Kd(bf) = 2(uM) | - | Substrate:
1345_3pase
IP3(134)
Products:
IP3(134)-3pase-c
mplx
|
| from Hoer et al, Biochem J 270; 1990 | | 19 | IP5-dipp-inhib | IHP-system
Pathway No. 168 | 1
(uM^-1 s^-1) | 1.6
(s^-1) | Kd(bf) = 1.6(uM) | - | Substrate:
DIPP1
IP5(13456)
Products:
IP5-DIPPcmplx
|
| IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998 | | 20 | IP6-dipp-inhib | IHP-system
Pathway No. 168 | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | Substrate:
IP6
DIPP1
Products:
IP6-DIPPcmplx
|
| IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998 |
and 
color.
