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Molecule Parameter List for CaMKII-thr286-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKII-thr286-CaM-PSD participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	3	0	1	2	0	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model0	59	Network	Shared_Object_AMPAR_traff_model0,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   PKA,  AC,  AMPAR,   AMPAR_memb
This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

CaMKII-thr286-CaM-PSD acting as a Molecule in  AMPAR_traff_model0 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-thr286-CaM-PSD	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	0	0.01	No

CaMKII-thr286-CaM-PSD acting as a Summed Molecule in  AMPAR_traff_model0 Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	actCaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD tot-auto-PSD
2	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	tot-CaM-CaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD
3	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	286P-PSD	CaMKII-thr286-Ca M-PSD CaMKII-thr286-PS D

CaMKII-thr286-CaM-PSD acting as a Substrate for an Enzyme in  AMPAR_traff_model0 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active_PSD  / Deph-thr286	AMPAR_traff_ model0 Accession No. : 59	PP1_PSD Pathway No. : 239	1.99994	2.5	4	explicit E-S complex	Substrate CaMKII-thr286-Ca M-PSD Product CaMKII-CaM-PSD

CaMKII-thr286-CaM-PSD acting as a Product of an Enzyme in  AMPAR_traff_model0 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-auto-PSD  / auton-286-PSD	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	125.001	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD
2	tot-CaM-CaMKII-P SD  / CaM-act-286-PSD	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	81.1694	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD

CaMKII-thr286-CaM-PSD acting as a Product in a reaction in  AMPAR_traff_model0 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	transloc_2	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	0 (#^-1 s^-1)	0 (s^-1)	Not applicable**	-	Substrate CaMKII-thr286*-C aM NMDAR Product CaMKII-thr286-Ca M-PSD
	Same as for transloc_1
2	CaMKII-thr286-bi nd-CaM-PSD	AMPAR_traff_ model0 Accession No. : 59	CaMKII Pathway No. : 235	1000.02 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0001(uM)	-	Substrate CaM-Ca4-PSD CaMKII-thr286-PS D Product CaMKII-thr286-Ca M-PSD
	Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?