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Molecule Parameter List for CaMKII***

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKII*** participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	0	2	2	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_traff_ model1	60	Network	Shared_Object_AMPAR_traff_model1,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   PKA,  AC,  AMPAR,   AMPAR_memb
This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable.

CaMKII*** acting as a Molecule in  AMPAR_traff_model1 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII***	AMPAR_traff_ model1 Accession No. : 60	CaMKII Pathway No. : 245	0	0.09	No
From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.

CaMKII*** acting as a Summed Molecule in  AMPAR_traff_model1 Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_traff_ model1 Accession No. : 60	CaMKII Pathway No. : 245	tot_autonomous_CaMKII	CaMKII-thr286 CaMKII*** basal_CaMKII_ cyt
2	AMPAR_traff_ model1 Accession No. : 60	CaMKII Pathway No. : 245	tot_CaMKII_cyt	CaMKII-CaM CaMKII-thr286*-C aM CaMKII-thr286 CaMKII*** CaMK-thr305 CaMKII basal_CaMKII_ cyt

CaMKII*** acting as a Substrate for an Enzyme in  AMPAR_traff_model1 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active  / Deph-thr305	AMPAR_traff_ model1 Accession No. : 60	PP1 Pathway No. : 247	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII*** Product CaMKII-thr286
2	PP1-active  / Deph-thr286c	AMPAR_traff_ model1 Accession No. : 60	PP1 Pathway No. : 247	5.09905	2.5	4	explicit E-S complex	Substrate CaMKII*** Product CaMK-thr305

CaMKII*** acting as a Product of an Enzyme in  AMPAR_traff_model1 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII  / CaM_act_305	AMPAR_traff_ model1 Accession No. : 60	CaMKII Pathway No. : 245	113.601	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_autonomous_ CaMKII  / auton_305	AMPAR_traff_ model1 Accession No. : 60	CaMKII Pathway No. : 245	175	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	See Hanson and Schulman again, for afterburst rates of phosph.