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Molecule Parameter List for CaMKII-thr286 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_traff_
model1 | 60 | Network |
Shared_Object_AMPAR_traff_model1, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
PKA, AC, AMPAR,
AMPAR_memb | | This is the basic model of AMPAR trafficking bistability. It is based on Hayer and Bhalla, PLoS Comput. Biol. 2005. It includes the degradation and turnover of AMPARs. The CaMKII portion of the model is not bistable. |
CaMKII-thr286 acting as a Molecule in AMPAR_traff_model1 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | CaMKII-thr286 | AMPAR_traff_
model1
Accession No. : 60 | CaMKII
Pathway No. : 245 | 0 | 0.09 | No | | I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off. |
CaMKII-thr286 acting as a Summed Molecule in AMPAR_traff_model1 Network
CaMKII-thr286 acting as a Substrate for an Enzyme in AMPAR_traff_model1 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | tot_CaM_CaMKII /
CaM_act_305 | AMPAR_traff_
model1
Accession No. : 60 | CaMKII
Pathway No. : 245 | 113.601 | 6 | 4 | explicit E-S complex | Substrate
CaMKII-thr286
Product
CaMKII***
| | | Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5. | | 2 | tot_autonomous_
CaMKII /
auton_305 | AMPAR_traff_
model1
Accession No. : 60 | CaMKII
Pathway No. : 245 | 175 | 6 | 4 | explicit E-S complex | Substrate
CaMKII-thr286
Product
CaMKII***
| | | See Hanson and Schulman again, for afterburst rates of phosph. | | 3 | PP1-active /
Deph-thr286b | AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 5.09905 | 2.5 | 4 | explicit E-S complex | Substrate
CaMKII-thr286
Product
CaMKII
|
CaMKII-thr286 acting as a Product of an Enzyme in AMPAR_traff_model1 Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PP1-active /
Deph-thr305 | AMPAR_traff_
model1
Accession No. : 60 | PP1
Pathway No. : 247 | 5.09905 | 2.5 | 4 | explicit E-S complex | Substrate
CaMKII***
Product
CaMKII-thr286
|
CaMKII-thr286 acting as a Substrate in a reaction in AMPAR_traff_model1 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | CaMK-thr286-bind
-CaM | AMPAR_traff_
model1
Accession No. : 60 | CaMKII
Pathway No. : 245 | 1000.19
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0001(uM) | - | Substrate
CaM-Ca4
CaMKII-thr286
Product
CaMKII-thr286*-C
aM
| | Affinity is up 1000X. Time to release is about 20 sec, so the kb is OK at 0.1 This makes Kf around 1.6666e-3 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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