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Molecule Parameter List for AC2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

AC2 participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	1	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_model3	63	Network	Shared_Object_CaMKII_model3,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   AC,  PKA
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

AC2 acting as a Molecule in  CaMKII_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
AC2	CaMKII_model3 Accession No. : 63	AC Pathway No. : 269	0.0741	0.09	No
Starting at 0.015 uM. 17 Feb 2005: Raised slightly so as to have integer number of molecules. 18 Feb 2005: Doubled, to compensate for reduced ATP.

AC2 acting as a Substrate for an Enzyme in  CaMKII_model3 Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PKC-active  / phosph-AC2	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	33.3337	4	4	explicit E-S complex	Substrate AC2 Product AC2*
Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4

AC2 acting as a Product in a reaction in  CaMKII_model3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
dephosph-AC2	CaMKII_model3 Accession No. : 63	AC Pathway No. : 269	0.1 (s^-1)	0 (s^-1)	-	-	Substrate AC2* Product AC2
Random rate.