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Molecule Parameter List for basal_CaMKII_PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

basal_CaMKII_PSD participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	0	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ weak_coupling	65	Network	Shared_Object_AMPAR_CaMKII_weak_coupling,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   AMPAR,  PKA,  AC,   AMPAR_memb,  PP1_CaMKII_PSD,  CaMKII_PSD
This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

basal_CaMKII_PSD acting as a Molecule in  AMPAR_CaMKII_weak_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
basal_CaMKII_PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	2	0.01	No

basal_CaMKII_PSD acting as a Summed Molecule in  AMPAR_CaMKII_weak_coupling Network

Accession Name	Pathway Name	Target	Input
AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	tot-auto-PSD	CaMKII-thr286-PS D CaMKII***-PSD basal_CaMKII_ PSD

basal_CaMKII_PSD acting as a Product in a reaction in  AMPAR_CaMKII_weak_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Stoch_Basal_ CaMKII_PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	1 (s^-1)	1 (s^-1)	Keq = 1(uM)	0.5sec	Substrate basal_CaMKII_ PSD_control Product basal_CaMKII_ PSD
This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations.