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Molecule Parameter List for basal_CaMKII_PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
basal_CaMKII_PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100001

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    weak_coupling
    		• 65Network
    Shared_Object_AMPAR_CaMKII_weak_coupling,  CaMKII,  CaM,  
    PP1,  PP2B,  PP1_PSD,  
    AMPAR,  PKA,  AC,  
    AMPAR_memb,  PP1_CaMKII_PSD,  CaMKII_PSD 
    This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

    basal_CaMKII_PSD acting as a Molecule in      AMPAR_CaMKII_weak_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    basal_CaMKII_PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		20.01No

    basal_CaMKII_PSD acting as a Summed Molecule in      AMPAR_CaMKII_weak_coupling Network
    Accession NamePathway NameTargetInput
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		tot-auto-PSD
  • CaMKII-thr286-PS
    D
    CaMKII***-PSD
  • basal_CaMKII_
    PSD

    • basal_CaMKII_PSD acting as a Product in a reaction in      AMPAR_CaMKII_weak_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • Stoch_Basal_
    CaMKII_PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		1
    (s^-1)    		1
    (s^-1)    		Keq = 1(uM)0.5secSubstrate
  • basal_CaMKII_
    PSD_control

    Product
  • basal_CaMKII_
    PSD
    • This reaction comes into play when stochastic calculations are used. If we do not have a stochastic step here then the levels of basal_CaMKII_PSD are just a fixed number, which is probably not a good representation of stochasticity. Having a reaction for the basal activity ensures that the basal activity too exhibits some fluctuations.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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