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Molecule Parameter List for CaMKII-thr286-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaMKII-thr286-PSD* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	0	3	3	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ weak_coupling	65	Network	Shared_Object_AMPAR_CaMKII_weak_coupling, CaMKII, CaM, PP1, PP2B, PP1_PSD, AMPAR, PKA, AC, AMPAR_memb, PP1_CaMKII_PSD, CaMKII_PSD
This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

CaMKII-thr286-PSD acting as a Molecule in AMPAR_CaMKII_weak_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-thr286-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	0	0.01	No

CaMKII-thr286-PSD acting as a Summed Molecule in AMPAR_CaMKII_weak_coupling Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	tot-auto-PSD	CaMKII-thr286-PS D CaMKII***-PSD basal_CaMKII_ PSD
2	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	286P-PSD	CaMKII-thr286-Ca M-PSD CaMKII-thr286-PS D

CaMKII-thr286-PSD acting as a Substrate for an Enzyme in AMPAR_CaMKII_weak_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active_ CaMKII_PSD / Deph-thr286b	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII-PSD
2	tot-CaM-CaMKII-P SD / CaM-act-305-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	320	6	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII***-PSD
3	tot-auto-PSD / auton-305-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	500	6	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII***-PSD

CaMKII-thr286-PSD acting as a Product of an Enzyme in AMPAR_CaMKII_weak_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active_ CaMKII_PSD / Deph-thr305	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII*-PSD Product** CaMKII-thr286-PS D
2	tot-CaM-CaMKII-P SD / CaM_act_autoph	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	320.002	2	4	explicit E-S complex	Substrate CaMKII-PSD Product CaMKII-thr286-PS D
3	tot-auto-PSD / auton-autoph	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	500.005	2	4	explicit E-S complex	Substrate CaMKII-PSD Product CaMKII-thr286-PS D

CaMKII-thr286-PSD acting as a Substrate in a reaction in AMPAR_CaMKII_weak_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMKII-thr286-bi nd-CaM-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	1000.02 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 0.0001(uM)	-	Substrate CaM-Ca4-PSD CaMKII-thr286-PS D Product CaMKII-thr286-Ca M-PSD
Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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