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Molecule Parameter List for CaMKII-PSD | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | AMPAR_CaMKII_
weak_coupling | 65 | Network |
Shared_Object_AMPAR_CaMKII_weak_coupling, CaMKII, CaM,
PP1, PP2B, PP1_PSD,
AMPAR, PKA, AC,
AMPAR_memb, PP1_CaMKII_PSD, CaMKII_PSD | | This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. |
CaMKII-PSD acting as a Molecule in AMPAR_CaMKII_weak_coupling Network
CaMKII-PSD acting as a Summed Molecule in AMPAR_CaMKII_weak_coupling Network
CaMKII-PSD acting as a Substrate for an Enzyme in AMPAR_CaMKII_weak_coupling Network
CaMKII-PSD acting as a Product of an Enzyme in AMPAR_CaMKII_weak_coupling Network
CaMKII-PSD acting as a Substrate in a reaction in AMPAR_CaMKII_weak_coupling Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | CaMKII-bind-CaM-
PSD | AMPAR_CaMKII_
weak_coupling
Accession No. : 65 | CaMKII_PSD
Pathway No. : 292 | 49.9998
(uM^-1 s^-1) | 0
(s^-1) | - | - | Substrate
CaM-Ca4-PSD
CaMKII-PSD
Product
CaMKII-CaM-PSD
| | 2 | back_1 | AMPAR_CaMKII_
weak_coupling
Accession No. : 65 | CaMKII_PSD
Pathway No. : 292 | 0.3
(s^-1) | 0
(#^-1 s^-1) | Not applicable** | - | Substrate
CaMKII-PSD
Product
CaMKII
NMDAR
| | | Rates set by the translocation experiments of Shen and Meyer, Science 1999. Note that this reaction also incorporates a translocation between compartments of different volumes. |
** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration
CaMKII-PSD acting as a Product in a reaction in AMPAR_CaMKII_weak_coupling Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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