|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for STAT1c | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | SOCS1_knockout | 67 | Pathway |
SOCS1_knockout | This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6
This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown.
The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations. |
STAT1c acting as a Molecule in SOCS1_knockout Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | STAT1c | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 1 | 0.0016667 | No | | STAT: Signal Transducer and Activator of Transcription STAT1c binds to IFNRJ2* and is phosphorylated by JAK. The phosphorylated STAT1 forms a homodimer which is translocated to the nucleus and works as transcription factors. STAT1c = 1000nM = 1uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
STAT1c acting as a Substrate in a reaction in SOCS1_knockout Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | STAT1c_
binding[2] | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 8
(uM^-1 s^-1) | 0.8
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate
SOCS1-IFNRJ2*
STAT1c
Product
SOCS1-IFNRJ2*-ST
AT1c
| | | Binding of STAT1c to JAK-IFNR phosphorylated dimer complexed with SOCS1 Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | | 2 | STAT1c_
binding[1] | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 8
(uM^-1 s^-1) | 0.8
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate
IFNRJ2*
STAT1c
Product
IFNRJ2*-STAT1c
| | | Binding of STAT1c to JAK-IFNR phosphorylated dimer Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | | 3 | STAT1c_
binding[3] | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 8
(uM^-1 s^-1) | 0.8
(s^-1) | Kd(bf) = 0.1(uM) | - | Substrate
SOCS1-IFNR2*-SHP
2
STAT1c
Product
SOCS1-IFNRJ2*-ST
AT1c-SHP-2
| | | Binding reaction of STAT1c kf = 8/sec/uM kb = 0.8/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196. |
STAT1c acting as a Product in a reaction in SOCS1_knockout Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | STAT1c*_
dephosphorylatio
n | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.003
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
PPX-STAT1c*
Product
PPX
STAT1c
| | | Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c Kf = 0.003/sec Kb = 0/sec/uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | | 2 | STAT1c*_
dephosphorylatio
n[1] | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.003
(s^-1) | 0
(uM^-2 s^-1) | - | - | Substrate
PPX-STAT1c*-STAT
1c*
Product
PPX
STAT1c
STAT1c*
| | | Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c dimer Kf = 0.003 Kb = 0 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | | 3 | STAT1n_
cytoplasmic_
transport | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.05
(s^-1) | 0
(s^-1) | - | - | Substrate
STAT1n
Product
STAT1c
| | | Transport of nucleoplasmic STAT1 to the cytoplasm Kf = 0.05 /sec/uM Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 | | 4 | dephospo_
IFNRJ2* | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.003
(s^-1) | 0
(uM^-2 s^-1) | - | - | Substrate
IFNRJ2*-STAT1c-S
HP2
Product
IFNRJ2
SHP-2
STAT1c
| | | Dephosphoryaltion of IFNRJ2* kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196. | | 5 | IFNRJ2*_
dephospo | SOCS1_knockout
Accession No. : 67 | SOCS1_knockout
Pathway No. : 294 | 0.003
(s^-1) | 0
(uM^-3 s^-1) | - | - | Substrate
SOCS1-IFNRJ2*-ST
AT1c-SHP-2
Product
IFNRJ2
SHP-2
SOCS1
STAT1c
| | | SHP-2 dephosphorylates JAK-IFNR dimer complexed with SOCS1 and STAT1c Kf = 0.003 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
