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Molecule Parameter List for STAT1c

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

STAT1c participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	3	5

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
SOCS1_knockout	67	Pathway	SOCS1_knockout
This model was taken from the Yamada S et al. FEBS Letters 2003 Jan 16;534(1-3):190-6 This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal transduction pathway. This is the knockout version of Jak-Stat pathway in this model the SOCS1 has been knocked out i.e it formation is not shown. The graphs are almost similar to the graphs as shown in the paper but STAT1n graph has some ambiguities. Thanks to Dr Satoshi Yamada for clarifying some of those ambiguities and providing the values used in the simulations.

STAT1c acting as a Molecule in  SOCS1_knockout Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
STAT1c	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	1	0.0016667	No
STAT: Signal Transducer and Activator of Transcription STAT1c binds to IFNRJ2* and is phosphorylated by JAK. The phosphorylated STAT1 forms a homodimer which is translocated to the nucleus and works as transcription factors. STAT1c = 1000nM = 1uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196

STAT1c acting as a Substrate in a reaction in  SOCS1_knockout Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	STAT1c_ binding[2]	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	8 (uM^-1 s^-1)	0.8 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate SOCS1-IFNRJ2* STAT1c Product SOCS1-IFNRJ2*-ST AT1c
	Binding of STAT1c to JAK-IFNR phosphorylated dimer complexed with SOCS1 Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
2	STAT1c_ binding[1]	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	8 (uM^-1 s^-1)	0.8 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate IFNRJ2* STAT1c Product IFNRJ2*-STAT1c
	Binding of STAT1c to JAK-IFNR phosphorylated dimer Kf = 8*10e+06 /M/sec = 8/uM/sec Kb = 0.8 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
3	STAT1c_ binding[3]	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	8 (uM^-1 s^-1)	0.8 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate SOCS1-IFNR2*-SHP 2 STAT1c Product SOCS1-IFNRJ2*-ST AT1c-SHP-2
	Binding reaction of STAT1c kf = 8/sec/uM kb = 0.8/sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534;190-196.

STAT1c acting as a Product in a reaction in  SOCS1_knockout Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	STAT1c*_ dephosphorylatio n	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	0.003 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate PPX-STAT1c* Product PPX STAT1c
	Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c Kf = 0.003/sec Kb = 0/sec/uM Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
2	STAT1c*_ dephosphorylatio n[1]	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	0.003 (s^-1)	0 (uM^-2 s^-1)	-	-	Substrate PPX-STAT1c*-STAT 1c* Product PPX STAT1c STAT1c*
	Cytoplasmic phosphatase (PPX) dephosphorylates STAT1c dimer Kf = 0.003 Kb = 0 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
3	STAT1n_ cytoplasmic_ transport	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	0.05 (s^-1)	0 (s^-1)	-	-	Substrate STAT1n Product STAT1c
	Transport of nucleoplasmic STAT1 to the cytoplasm Kf = 0.05 /sec/uM Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196
4	dephospo_ IFNRJ2*	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	0.003 (s^-1)	0 (uM^-2 s^-1)	-	-	Substrate IFNRJ2*-STAT1c-S HP2 Product IFNRJ2 SHP-2 STAT1c
	Dephosphoryaltion of IFNRJ2* kf = 0.003/sec kb = 0/sec/uM^2 Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196.
5	IFNRJ2*_ dephospo	SOCS1_knockout Accession No. : 67	SOCS1_knockout Pathway No. : 294	0.003 (s^-1)	0 (uM^-3 s^-1)	-	-	Substrate SOCS1-IFNRJ2*-ST AT1c-SHP-2 Product IFNRJ2 SHP-2 SOCS1 STAT1c
	SHP-2 dephosphorylates JAK-IFNR dimer complexed with SOCS1 and STAT1c Kf = 0.003 /sec Kb = 0 /sec Appendix, Satoshi Yamada et al 2003 FEBS Letters 534:190-196