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Molecule Parameter List for MAPKK*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPKK* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences25050255000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    		• 81NetworkShared_Object_Ajay_bhalla_2007_ReacDiff1_1e-12,  
    PKC,  MAPK,  Ras,  CaM,  PKM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[1],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[2],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[3],  
    PKC,  MAPK,  MAPK,  Ras,  CaM,  PKM,  kinetics[4],  PKC,  MAPK,  Ras,  CaM,  PKM,  
    kinetics[5],  PKC,  MAPK,  Ras,  kinetics[6],  CaM,  PKM,  PKC,  MAPK,  Ras,  
    CaM,  PKM,  kinetics[7],  PKC,  Ras,  CaM,  PKM,  kinetics[8],  PKC,  MAPK,  
    Ras,  CaM,  PKM,  kinetics[9],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[10],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[11],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[12],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[13],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[14],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[15],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[16],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[17],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[18],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[19],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[20],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[21],  PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[22],  
    PKC,  MAPK,  Ras,  CaM,  PKM,  kinetics[23],  PKC,  MAPK,  Ras,  CaM,  PKM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
    The stimulus file pkm_mapk22_diff_1e-12_Fig4A which was used for the model to replicate Figure 4A from the paper.
    This stimulus file pkm_mapk22_diff_1e-12_Fig4G which was used for the model to replicate Figure 4G from the paper

    MAPKK* acting as a Molecule in      Ajay_bhalla_2007_ReacDiff1_1e-12 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 377    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 384    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 390    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 396    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 403    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 409    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 415    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 421    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 402    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 432    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 438    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 444    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 450    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 456    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 462    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 468    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 474    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 480    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 486    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 492    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 498    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 504    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 510    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 516    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992
    MAPKK*
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 522    		01.5No
    MAPKK phosphorylates MAPK on both the tyr and thr residues, first tyr then thr. Refs: Seger et al JBC267:20 pp 14373 1992 The MAPKK itself is phosphorylated on ser as well as thr residues. Let us assume that the ser goes first, and that the sequential phosphorylation is needed. See Kyriakis et al Nature 358 417-421 1992

    MAPKK* acting as an Enzyme in      Ajay_bhalla_2007_ReacDiff1_1e-12 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 377    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    2MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 377    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    3MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 384    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    4MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 384    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    5MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 390    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    6MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 390    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    7MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 396    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    8MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 396    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    9MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 403    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    10MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 403    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    11MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 409    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    12MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 409    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    13MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 415    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    14MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 415    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    15MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 421    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    16MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 421    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    17MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 402    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    18MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 402    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    19MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 432    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    20MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 432    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    21MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 438    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    22MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 438    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    23MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 444    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    24MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 444    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    25MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 450    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    26MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 450    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    27MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 456    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    28MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 456    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    29MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 462    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    30MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 462    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    31MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 468    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    32MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 468    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    33MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 474    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    34MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 474    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    35MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 480    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    36MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 480    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    37MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 486    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    38MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 486    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    39MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 492    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    40MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 492    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    41MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 498    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    42MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 498    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    43MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 504    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    44MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 504    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    45MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 510    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    46MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 510    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    47MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 516    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    48MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 516    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.
    49MAPKK* /
    MAPKKtyr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 522    		0.04629640.34explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
        The actual MAPKK is 2 forms from Seger et al JBC 267:20 14373(1992) Vmax = 150nmol/min/mg From Haystead et al FEBS 306(1):17-22 we get Km=46.6nM for at least one of the phosphs. Putting these together: k3=0.15/sec, scale to get k2=0.6. k1=0.75/46.6nM=2.7e-5
    50MAPKK* /
    MAPKKthr
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 522    		0.04629640.34explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK*
        Rate consts same as for MAPKKtyr.

    MAPKK* acting as a Substrate for an Enzyme in      Ajay_bhalla_2007_ReacDiff1_1e-12 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
  • Shared_Object_
    Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Pathway No. : 375
    		• 15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    2PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics
    Pathway No. : 382    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    3PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[1]
    Pathway No. : 388    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    4PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[2]
    Pathway No. : 394    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    5PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[3]
    Pathway No. : 400    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    6PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[4]
    Pathway No. : 407    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    7PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[5]
    Pathway No. : 413    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    8PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[6]
    Pathway No. : 417    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    9PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[7]
    Pathway No. : 425    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    10PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[8]
    Pathway No. : 430    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    11PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[9]
    Pathway No. : 436    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    12PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[10]
    Pathway No. : 442    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    13PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[11]
    Pathway No. : 448    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    14PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[12]
    Pathway No. : 454    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    15PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[13]
    Pathway No. : 460    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    16PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[14]
    Pathway No. : 466    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    17PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[15]
    Pathway No. : 472    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    18PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[16]
    Pathway No. : 478    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    19PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[17]
    Pathway No. : 484    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    20PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[18]
    Pathway No. : 490    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    21PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[19]
    Pathway No. : 496    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    22PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[20]
    Pathway No. : 502    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    23PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[21]
    Pathway No. : 508    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    24PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[22]
    Pathway No. : 514    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.
    25PPhosphatase2A  /
    MAPKK-deph
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• kinetics[23]
    Pathway No. : 520    		15.656764explicit E-S complexSubstrate
    MAPKK*

    Product
    MAPKK-ser
        See: Kyriakis et al Nature 358 pp 417-421 1992 Ahn et al Curr Op Cell Biol 4:992-999 1992 for this pathway. See parent PPhosphatase2A for parms.

    MAPKK* acting as a Product of an Enzyme in      Ajay_bhalla_2007_ReacDiff1_1e-12 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 377    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    2Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 377    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    3Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 384    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    4Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 384    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    5Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 390    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    6Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 390    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    7Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 396    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    8Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 396    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    9Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 403    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    10Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 403    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    11Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 409    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    12Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 409    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    13Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 415    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    14Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 415    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    15Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 421    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    16Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 421    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    17Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 402    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    18Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 402    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    19Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 432    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    20Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 432    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    21Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 438    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    22Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 438    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    23Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 444    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    24Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 444    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    25Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 450    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    26Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 450    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    27Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 456    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    28Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 456    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    29Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 462    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    30Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 462    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    31Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 468    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    32Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 468    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    33Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 474    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    34Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 474    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    35Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 480    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    36Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 480    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    37Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 486    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    38Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 486    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    39Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 492    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    40Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 492    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    41Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 498    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    42Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 498    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    43Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 504    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    44Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 504    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    45Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 510    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    46Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 510    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    47Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 516    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    48Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 516    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6
    49Raf-GTP-Ras  /
    Raf-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 522    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Kinetics are the same as for the craf_1* activity, ie., k1=5.5e-6, k2=0.42, k3 = 0.105 These are basedo n Force et al PNAS USA 91 1270-1274, 1994., but k1 is scaled up 5x (ie., Km is scaled down 5x to the value used here and for craf_1* activity: Km = 0.1591).
    50Raf*-GTP-Ras  /
    Raf*-GTP-Ras.2
  • Ajay_bhalla_
    2007_ReacDiff1_
    1e-12
    Accession No. : 81
    		• MAPK
    Pathway No. : 522    		0.1590960.34explicit E-S complexSubstrate
    MAPKK-ser

    Product
    MAPKK*
        Same kinetics as other c-raf activated forms. See Force et al PNAS 91 1270-1274 1994. k1 = 1.1e-6, k2 = .42, k3 = 1.05 raise k1 to 5.5e-6


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