|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for inact-GEF | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_bhalla_
2007_ReacDiff1_
1e-12 | 81 | Network | Shared_Object_Ajay_bhalla_2007_ReacDiff1_1e-12,
PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1],
PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3],
PKC, MAPK, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM,
kinetics[5], PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras,
CaM, PKM, kinetics[7], PKC, Ras, CaM, PKM, kinetics[8], PKC, MAPK,
Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10],
PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12],
PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14],
PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16],
PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18],
PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20],
PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22],
PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec.
The stimulus file pkm_mapk22_diff_1e-12_Fig4A which was used for the model to replicate Figure 4A from the paper.
This stimulus file pkm_mapk22_diff_1e-12_Fig4G which was used for the model to replicate Figure 4G from the paper |
inact-GEF acting as a Molecule in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 0.1 | 1.5 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. |
inact-GEF acting as an Enzyme in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
inact-GEF acting as a Substrate for an Enzyme in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 2 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics
Pathway No. : 382 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 3 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[1]
Pathway No. : 388 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 4 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[2]
Pathway No. : 394 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 5 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[3]
Pathway No. : 400 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 6 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[4]
Pathway No. : 407 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 7 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[5]
Pathway No. : 413 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 8 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[6]
Pathway No. : 417 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 9 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[7]
Pathway No. : 425 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 10 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[8]
Pathway No. : 430 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 11 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[9]
Pathway No. : 436 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 12 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[10]
Pathway No. : 442 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 13 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[11]
Pathway No. : 448 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 14 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[12]
Pathway No. : 454 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 15 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[13]
Pathway No. : 460 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 16 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[14]
Pathway No. : 466 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 17 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[15]
Pathway No. : 472 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 18 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[16]
Pathway No. : 478 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 19 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[17]
Pathway No. : 484 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 20 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[18]
Pathway No. : 490 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 21 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[19]
Pathway No. : 496 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 22 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[20]
Pathway No. : 502 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 23 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[21]
Pathway No. : 508 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 24 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[22]
Pathway No. : 514 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 25 | PKC-active /
PKC-act-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | kinetics[23]
Pathway No. : 520 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X |
inact-GEF acting as a Substrate in a reaction in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 2 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 378 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 3 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 4 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 385 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 5 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 6 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 391 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 7 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 8 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 397 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 9 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 10 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 404 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 11 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 12 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 410 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 13 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 14 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 416 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 15 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 16 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 422 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 17 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 18 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 427 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 19 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 20 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 433 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 21 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 22 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 439 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 23 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 24 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 445 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 25 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 26 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 451 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 27 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 28 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 457 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 29 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 30 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 463 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 31 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 32 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 469 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 33 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 34 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 475 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 35 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 36 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 481 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 37 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 38 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 487 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 39 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 40 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 493 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 41 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 42 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 499 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 43 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 44 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 505 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 45 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 46 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 511 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 47 | diff | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Shared_Object_
Ajay_bhalla_
2007_ReacDiff1_
1e-12
Pathway No. : 375 | 0.01
(s^-1) | 0.01
(s^-1) | Keq = 1(uM) | 50sec | Substrate
inact-GEF
Product
inact-GEF
| | 48 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 517 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 | | 49 | CaM-bind-GEF | Ajay_bhalla_
2007_ReacDiff1_
1e-12
Accession No. : 81 | Ras
Pathway No. : 523 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 |
inact-GEF acting as a Product in a reaction in Ajay_bhalla_2007_ReacDiff1_1e-12 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
