|
Enter a Search String | | Special character and space not allowed in the query term.
Search string should be at least 2 characters long. |
Molecule Parameter List for GAP | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2007_ReacDiff3 | 84 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff3, PKC, PLA2,
MAPK, PLA2, Ras, CaM, chain, kinetics, PKC, MAPK, Ras, CaM, kinetics[1],
PKC, PLA2, MAPK, Ras, CaM, kinetics[2], PKC, PLA2, MAPK, Ras, CaM, kinetics[3],
PKC, PLA2, MAPK, Ras, CaM, kinetics[4], PKC, PLA2, MAPK, Ras, CaM, kinetics[5],
PKC, PLA2, MAPK, Ras, MAPK, CaM, kinetics[6], PKC, PLA2, MAPK, Ras,
CaM, kinetics[7], PKC, PLA2, MAPK, Ras, CaM, PKC, kinetics[8], PLA2,
MAPK, Ras, CaM, kinetics[9], PKC, PLA2, MAPK, Ras, CaM, kinetics[10],
PKC, PLA2, MAPK, Ras, CaM, kinetics[11], PKC, PLA2, MAPK, Ras, CaM,
kinetics[12], PKC, PLA2, Ras, CaM, kinetics[13], PKC, PLA2, MAPK,
Ras, CaM, kinetics[14], PKC, PLA2, MAPK, Ras, CaM, kinetics[15],
PKC, PLA2, MAPK, Ras, kinetics[16], CaM, PKC, PLA2, MAPK, Ras, CaM,
kinetics[17], PKC, PLA2, MAPK, Ras, CaM, kinetics[18], PKC, PLA2,
MAPK, Ras, CaM, kinetics[19], PKC, PLA2, MAPK, Ras, CaM, kinetics[20],
PKC, PLA2, MAPK, Ras, CaM, kinetics[21], PKC, PLA2, MAPK, Ras, CaM,
kinetics[22], PKC, PLA2, MAPK, Ras, CaM, kinetics[23], PKC, PLA2,
MAPK, Ras, CaM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. |
GAP acting as a Molecule in Ajay_Bhalla_2007_ReacDiff3 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 923 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 929 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 935 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 941 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 947 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 953 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 959 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 966 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 972 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 978 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 984 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 990 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 996 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1001 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1007 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1013 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1019 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1025 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1031 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1037 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1043 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1049 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1055 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1061 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. | | GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1067 | 0.01 | 125.7 | No | | GTPase-activating proteins. See Boguski and McCormick. Turn off Ras by helping to hydrolyze bound GTP. This one is probably NF1, ie., Neurofibromin as it is inhibited by AA and lipids, and expressed in neural cells. p120-GAP is also a possible candidate, but is less regulated. Both may exist at similar levels. See Eccleston et al JBC 268(36) pp27012-19 Level=.002 16 May 2003: Increased level to 0.0036, in line with other concentration raises at the synapse. |
GAP acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff3 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 923 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 2 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 929 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 3 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 935 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 4 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 941 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 5 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 947 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 6 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 953 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 7 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 959 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 8 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 966 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 9 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 972 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 10 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 978 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 11 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 984 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 12 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 990 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 13 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 996 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 14 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1001 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 15 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1007 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 16 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1013 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 17 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1019 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 18 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1025 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 19 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1031 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 20 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1037 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 21 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1043 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 22 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1049 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 23 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1055 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 24 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1061 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. | | 25 | GAP /
GAP-inact-ras
| Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1067 | 1.0104 | 10 | 4 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
| | | From Eccleston et al JBC 268(36)pp27012-19 get Kd < 2uM, kcat - 10/sec From Martin et al Cell 63 843-849 1990 get Kd ~ 250 nM, kcat = 20/min I will go with the Eccleston figures as there are good error bars (10%). In general the values are reasonably close. k1 = 1.666e-3/sec, k2 = 1000/sec, k3 = 10/sec (note k3 is rate-limiting) 5 Nov 2002: Changed ratio term to 4 from 100. Now we have k1=8.25e-5; k2=40, k3=10. k3 is still rate-limiting. |
GAP acting as a Substrate for an Enzyme in Ajay_Bhalla_2007_ReacDiff3 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 2 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics
Pathway No. : 926 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 3 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[1]
Pathway No. : 931 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 4 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[2]
Pathway No. : 937 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 5 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[3]
Pathway No. : 943 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 6 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[4]
Pathway No. : 949 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 7 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[5]
Pathway No. : 955 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 8 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[6]
Pathway No. : 962 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 9 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[7]
Pathway No. : 968 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 10 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[8]
Pathway No. : 975 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 11 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[9]
Pathway No. : 980 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 12 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[10]
Pathway No. : 986 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 13 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[11]
Pathway No. : 992 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 14 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[12]
Pathway No. : 998 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 15 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[13]
Pathway No. : 1003 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 16 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[14]
Pathway No. : 1009 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 17 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[15]
Pathway No. : 1015 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 18 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[16]
Pathway No. : 1020 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 19 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[17]
Pathway No. : 1027 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 20 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[18]
Pathway No. : 1033 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 21 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[19]
Pathway No. : 1039 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 22 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[20]
Pathway No. : 1045 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 23 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[21]
Pathway No. : 1051 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 24 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[22]
Pathway No. : 1057 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. | | 25 | PKC-active /
PKC-inact-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[23]
Pathway No. : 1063 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
| | | Rate consts copied from PCK-act-raf This reaction inactivates GAP. The idea is from the Boguski and McCormick review. |
GAP acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
GAP acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 923 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 2 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 3 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 929 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 4 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 5 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 935 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 6 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 7 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 8 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 941 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 9 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 10 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 947 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 11 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 12 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 953 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 13 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 14 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 959 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 15 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 966 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 16 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 17 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 972 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 18 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 19 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 978 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 20 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 21 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 984 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 22 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 23 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 990 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 24 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 25 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 996 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 26 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 27 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1001 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 28 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 29 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1007 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 30 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 31 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1013 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 32 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 33 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1019 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 34 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 35 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1025 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 36 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 37 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1031 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 38 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 39 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1037 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 40 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 41 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1043 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 42 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 43 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1049 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 44 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 45 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1055 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 46 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 47 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1061 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec | | 48 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
GAP
Product
GAP
| | 49 | dephosph-GAP | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1067 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
| | | Assume a reasonably good rate for dephosphorylating it, 1/sec |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
