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Molecule List for pathway CaMKII (Pathway Number 235) in Accession AMPAR_traff_model0 (Accession Number 59)

Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.

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The entries are grouped according to Pathway Number and are alternately color coded using

and

color.

	Name	Accession Type	Initial Conc. (uM)	Volume (fL)	Buffered	Sum Total Of
1	tot_CaM_CaMKII	Network	0	0.09	No	CaMKII-CaM CaMKII-thr286*-C aM
2	tot_CaMKII_PSD	Network	2	0.01	No	actCaMKII-PSD CaMKII-PSD CaMKII-thr305-PS D
3	tot_CaMKII_cyt	Network	22	0.09	No	CaMKII-CaM CaMKII-thr286-C aM CaMKII-thr286 CaMKII** CaMK-thr305 CaMKII basal_CaMKII_ cyt
4	tot_autonomous_ CaMKII	Network	2	0.09	No	CaMKII-thr286 CaMKII*** basal_CaMKII_ cyt
5	tot-CaM-CaMKII-P SD	Network	0	0.01	No	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD
6	tot-auto-PSD	Network	2	0.01	No	CaMKII-thr286-PS D CaMKII***-PSD basal_CaMKII_ PSD
7	NMDAR	Network	120	0.01	No	-
	The stochiometry is a bit off here. Each NMDAR actually binds to a holoenzyme, about 12 CaMKII subunits. But our CaMKII calculations are in terms of individual subunits. So as a hack, we put in much more NMDAR than is actually there.
8	CaMKII-thr305-PS D	Network	0	0.01	No	-
9	CaMKII-thr286-PS D	Network	0	0.01	No	-
10	CaMKII-thr286-Ca M-PSD	Network	0	0.01	No	-
11	CaMKII-thr286*-C aM	Network	0	0.09	No	-
	From Hanson and Schulman, the thr286 is responsible for autonomous activation of CaMKII.
12	CaMKII-thr286	Network	0	0.09	No	-
	I am not sure if we need to endow this one with a lot of enzs. It is likely to be a short-lived intermediate, since it will be phosphorylated further as soon as the CAM falls off.
13	CaMKII-PSD	Network	0	0.01	No	-
14	CaMKII-CaM-PSD	Network	0	0.01	No	-
15	CaMKII-CaM	Network	0	0.09	No	-
16	CaMKII***-PSD	Network	0	0.01	No	-
17	CaMKII***	Network	0	0.09	No	-
	From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
18	CaMKII	Network	20	0.09	No	-
	Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit. This comes to about 70 uM.
19	CaMK-thr305	Network	0	0.09	No	-
	This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
20	basal_CaMKII_ PSD_control	Network	2	0.01	Yes	-