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Accession Type:
Network
AMPAR_CaMKII_
strong_coupling
Shared_Object_
AMPAR_CaMKII_
strong_coupling
 Molecule
 Enzyme
 Reaction
CaMKII
CaM
PP1
AMPAR_memb
PP2B
PKA
AC
PP1_PSD
AMPAR

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Enzyme List for pathway Shared_Object_AMPAR_CaMKII_strong_coupling (Pathway Number 271)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
auton-286-PSD

Enzyme Molecule:
tot-auto-PSD		500.0020.54explicit E-S complexCaMKII-CaM-PSD
  • CaMKII-thr286-Ca
    M-PSD
    • 2 Enzyme Activity:
    auton-305-PSD

    Enzyme Molecule:
    tot-auto-PSD    		50064explicit E-S complex
  • CaMKII-thr286-PS
    D
    		• CaMKII***-PSD
    3 Enzyme Activity:
    auton-autoph

    Enzyme Molecule:
    tot-auto-PSD    		500.00524explicit E-S complexCaMKII-PSD
  • CaMKII-thr286-PS
    D
    • 4 Enzyme Activity:
    CaM-act-286-PSD

    Enzyme Molecule:
    tot-CaM-CaMKII-P
    SD    		319.9960.54explicit E-S complexCaMKII-CaM-PSD
  • CaMKII-thr286-Ca
    M-PSD
    • 5 Enzyme Activity:
    CaM-act-305-PSD

    Enzyme Molecule:
    tot-CaM-CaMKII-P
    SD    		32064explicit E-S complex
  • CaMKII-thr286-PS
    D
    		• CaMKII***-PSD
    6 Enzyme Activity:
    CaMKII

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B845*
    		A831*845*_B845*
    7 Enzyme Activity:
    CaMKII[10]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B831*
    		A831*845*_B831*
    8 Enzyme Activity:
    CaMKII[11]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B831*
    		A831*_B831*
    9 Enzyme Activity:
    CaMKII[12]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*845*_B845*
  • A835*845*_
    B835*845*
    • 10 Enzyme Activity:
    CaMKII[13]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*_B845*
    		A831*_B831*845*
    11 Enzyme Activity:
    CaMKII[14]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*845*_B
    		A831*845*_B831*
    12 Enzyme Activity:
    CaMKII[15]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA831*_B
    		A831*_B831*
    13 Enzyme Activity:
    CaMKII[1]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B845*
    		A831*_B845*
    14 Enzyme Activity:
    CaMKII[2]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B
    		A831*845*_B
    15 Enzyme Activity:
    CaMKII[3]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B
    		A831*_B
    16 Enzyme Activity:
    CaMKII[4]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B845*
    		A845*_B831*845*
    17 Enzyme Activity:
    CaMKII[5]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B845*
    		A_B831*845*
    18 Enzyme Activity:
    CaMKII[6]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B
    		A845*_B831*
    19 Enzyme Activity:
    CaMKII[7]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B
    		A_B831*
    20 Enzyme Activity:
    CaMKII[8]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA845*_B831*845*
  • A835*845*_
    B835*845*
    • 21 Enzyme Activity:
    CaMKII[9]

    Enzyme Molecule:
    actCaMKII-PSD    		90.00060.54explicit E-S complexA_B831*845*
    		A831*_B831*845*
    22 Enzyme Activity:
    CaM_act_autoph

    Enzyme Molecule:
    tot-CaM-CaMKII-P
    SD    		320.00224explicit E-S complexCaMKII-PSD
  • CaMKII-thr286-PS
    D
    • 23 Enzyme Activity:
    Deph-thr286

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complex
  • CaMKII-thr286*-C
    aM
    		• CaMKII-CaM
    24 Enzyme Activity:
    Deph-thr286

    Enzyme Molecule:
    PP1-active_PSD    		2.000010.24explicit E-S complex
  • CaMKII-thr286-Ca
    M-PSD
    		• CaMKII-CaM-PSD
    25 Enzyme Activity:
    Deph-thr286b

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMKII-thr286
    		CaMKII
    26 Enzyme Activity:
    Deph-thr286b

    Enzyme Molecule:
    PP1-active_PSD    		2.000010.24explicit E-S complex
  • CaMKII-thr286-PS
    D
    		• CaMKII-PSD
    27 Enzyme Activity:
    Deph-thr286c

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMKII***
    		CaMK-thr305
    28 Enzyme Activity:
    Deph-thr286c

    Enzyme Molecule:
    PP1-active_PSD    		2.000010.24explicit E-S complexCaMKII***-PSD
  • CaMKII-thr305-PS
    D
    • 29 Enzyme Activity:
    Deph-thr305

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMKII***
    		CaMKII-thr286
    30 Enzyme Activity:
    Deph-thr305

    Enzyme Molecule:
    PP1-active_PSD    		2.000010.24explicit E-S complexCaMKII***-PSD
  • CaMKII-thr286-PS
    D
    • 31 Enzyme Activity:
    Deph-thr305a

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMK-thr305
    		CaMKII
    32 Enzyme Activity:
    Deph-thr305a

    Enzyme Molecule:
    PP1-active_PSD    		2.000010.24explicit E-S complex
  • CaMKII-thr305-PS
    D
    		• CaMKII-PSD
    33 Enzyme Activity:
    dephosph-PP1-I*

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970790.344explicit E-S complexPP1-I1*
    		PP1-I1
    34 Enzyme Activity:

    dephosph-PP1-I*_
    PSD

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970710.344explicit E-S complexPP1-I1*
    		PP1-I1
    35 Enzyme Activity:
    dephosph_inhib1

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970790.344explicit E-S complexI1*
    		I1
    36 Enzyme Activity:
    dephosph_
    inhib1_noCaM

    Enzyme Molecule:
    CaNAB-Ca4    		4.970790.0344explicit E-S complexI1*
    		I1
      The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
    37 Enzyme Activity:
    dephosph_
    inhib1_noCaM_
    PSD

    Enzyme Molecule:
    CaNAB-Ca4    		4.970710.0344explicit E-S complexI1*
    		I1
      The rates here are so slow I do not know if we should even bother with this enz reacn. These numbers are from Liu and Storm. Other refs suggest that the Km stays the same but the Vmax goes to 10% of the CaM stim levels. Prev: k1=2.2e-9, k2 = 0.0052, k3 = 0.0013 New : k1=5.7e-8, k2=.136, k3=.034
    38 Enzyme Activity:
    dephosph_
    inhib1_PSD

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.970710.344explicit E-S complexI1*
    		I1
    39 Enzyme Activity:
    dephosph_
    neurogranin

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		10.0120.673.98507explicit E-S complexneurogranin*
    		neurogranin
      From Seki et al ABB 316(2):673-679
    40 Enzyme Activity:
    dephosph_
    neurogranin_PSD

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		10.0120.673.98507explicit E-S complex
  • neurogranin*_
    PSD
    		• neurogranin_PSD
      From Seki et al ABB 316(2):673-679
    41 Enzyme Activity:
    phosph-AC2

    Enzyme Molecule:
    PKC-active    		33.333744explicit E-S complexAC2
    		AC2*
      Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
    42 Enzyme Activity:
    phosph-PDE

    Enzyme Molecule:
    PKA-active    		7.5000894explicit E-S complexcAMP-PDE
    		cAMP-PDE*
      Same rates as PKA-phosph-I1
    43 Enzyme Activity:
    PKA

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B845*
    		A845*_B845*
    44 Enzyme Activity:
    PKA-phosph-I1

    Enzyme Molecule:
    PKA-active    		7.5000894explicit E-S complexI1
    		I1*
      #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
    45 Enzyme Activity:
    PKA-phosph-I1_
    PSD

    Enzyme Molecule:
    PKA-active    		7.5000894explicit E-S complexI1
    		I1*
    46 Enzyme Activity:
    PKA[10]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*
    		A_B831*845*
    47 Enzyme Activity:
    PKA[11]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*
    		A845*_B831*
    48 Enzyme Activity:
    PKA[12]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*845*
  • A835*845*_
    B835*845*
    • 49 Enzyme Activity:
    PKA[13]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B831*
  • A835*845*_
    B835*845*
    • 50 Enzyme Activity:
    PKA[14]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*_B831*845*
    51 Enzyme Activity:
    PKA[15]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*845*_B831*
    52 Enzyme Activity:
    PKA[16]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*845*_B
    53 Enzyme Activity:
    PKA[17]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A845*_B
    54 Enzyme Activity:
    PKA[18]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*
    		A845*_B831*
    55 Enzyme Activity:
    PKA[19]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*845*_B831*
    56 Enzyme Activity:
    PKA[1]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B
    		A845*_B845*
    57 Enzyme Activity:
    PKA[20]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A_B845*
    58 Enzyme Activity:
    PKA[21]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*_B845*
    59 Enzyme Activity:
    PKA[22]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*
    		A_B831*845*
    60 Enzyme Activity:
    PKA[23]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*
    		A831*_B831*845*
    61 Enzyme Activity:
    PKA[24]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B845*
    		A845*_B845*
    62 Enzyme Activity:
    PKA[25]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B845*
    		A831*845*_B845*
    63 Enzyme Activity:
    PKA[26]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*845*
    		A845*_B831*845*
    64 Enzyme Activity:
    PKA[27]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B831*845*
  • A835*845*_
    B835*845*
    • 65 Enzyme Activity:
    PKA[28]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B
    		A845*_B845*
    66 Enzyme Activity:
    PKA[29]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B
    		A831*845*_B845*
    67 Enzyme Activity:
    PKA[2]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A845*_B
    68 Enzyme Activity:
    PKA[30]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B831*
    		A845*_B831*845*
    69 Enzyme Activity:
    PKA[31]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B831*
  • A835*845*_
    B835*845*
    • 70 Enzyme Activity:
    PKA[3]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B
    		A_B845*
    71 Enzyme Activity:
    PKA[4]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B845*
    		A831*845*_B845*
    72 Enzyme Activity:
    PKA[5]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*845*_B
    		A831*845*_B845*
    73 Enzyme Activity:
    PKA[6]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*_B845*
    74 Enzyme Activity:
    PKA[7]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA831*_B
    		A831*845*_B
    75 Enzyme Activity:
    PKA[8]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA_B831*845*
    		A845*_B831*845*
    76 Enzyme Activity:
    PKA[9]

    Enzyme Molecule:
    PKA-active    		7.5002164explicit E-S complexA845*_B831*
    		A845*_B831*845*
    77 Enzyme Activity:
    PKC-phosph-neuro
    granin

    Enzyme Molecule:
    PKC-active    		28.62730.584.03448explicit E-S complexneurogranin
    		neurogranin*
      Rates from Huang et al ABB 305:2 570-580 1993
    78 Enzyme Activity:

    PKC-phosph-neuro
    granin_
    PSD

    Enzyme Molecule:
    PKC-active    		28.62730.584.03448explicit E-S complexneurogranin_PSD
  • neurogranin*_
    PSD
    •   Rates from Huang et al ABB 305:2 570-580 1993
    79 Enzyme Activity:
    PKC-phosph-ng-Ca
    M

    Enzyme Molecule:
    PKC-active    		28.59560.354explicit E-S complexneurogranin-CaM
    		CaM
    neurogranin*
      Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
    80 Enzyme Activity:

    PKC-phosph-ng-Ca
    M_
    PSD

    Enzyme Molecule:
    PKC-active    		28.59560.354explicit E-S complex

  • neurogranin-CaM_
    PSD
    		• CaM-PSD
  • neurogranin*_
    PSD
    •   Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
    81 Enzyme Activity:
    PP1

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA845*_B845*
    		A_B845*
    82 Enzyme Activity:
    PP1[10]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*845*_B
    		A845*_B
    83 Enzyme Activity:
    PP1[11]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*_B
    		A_B
    84 Enzyme Activity:
    PP1[12]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA845*_B831*845*
    		A_B831*845*
    85 Enzyme Activity:
    PP1[13]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA845*_B831*845*
    		A845*_B831*
    86 Enzyme Activity:
    PP1[14]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA_B831*845*
    		A_B831*
    87 Enzyme Activity:
    PP1[15]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA845*_B831*
    		A_B831*
    88 Enzyme Activity:
    PP1[16]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*_B831*845*
    89 Enzyme Activity:
    PP1[17]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*845*_B831*
    90 Enzyme Activity:
    PP1[18]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA831*_B831*845*
    		A831*_B831*
    91 Enzyme Activity:
    PP1[19]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA831*845*_B831*
    		A831*_B831*
    92 Enzyme Activity:
    PP1[1]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA845*_B845*
    		A845*_B
    93 Enzyme Activity:
    PP1[20]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA_B831*845*
    		A_B845*
    94 Enzyme Activity:
    PP1[21]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA845*_B831*845*
    		A845*_B845*
    95 Enzyme Activity:
    PP1[22]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA845*_B831*
    		A845*_B
    96 Enzyme Activity:
    PP1[23]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA_B831*
    		A_B
    97 Enzyme Activity:
    PP1[24]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complex
  • A835*845*_
    B835*845*
    		• A845*_B831*845*
    98 Enzyme Activity:
    PP1[25]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*_B831*845*
    		A_B831*845*
    99 Enzyme Activity:
    PP1[26]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*845*_B831*
    		A845*_B831*
    100 Enzyme Activity:
    PP1[27]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*_B831*
    		A_B831*
    101 Enzyme Activity:
    PP1[28]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*845*_B845*
    102 Enzyme Activity:
    PP1[29]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*_B831*845*
    		A831*_B845*
    103 Enzyme Activity:
    PP1[2]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA845*_B
    		A_B
    104 Enzyme Activity:
    PP1[30]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*845*_B831*
    		A831*845*_B
    105 Enzyme Activity:
    PP1[31]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*_B831*
    		A831*_B
    106 Enzyme Activity:
    PP1[3]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA_B845*
    		A_B
    107 Enzyme Activity:
    PP1[4]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA831*845*_B845*
    		A831*_B845*
    108 Enzyme Activity:
    PP1[5]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA831*845*_B845*
    		A831*845*_B
    109 Enzyme Activity:
    PP1[6]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA831*_B845*
    		A831*_B
    110 Enzyme Activity:
    PP1[7]

    Enzyme Molecule:
    PP1-active_PSD    		0.9714510.174explicit E-S complexA831*845*_B
    		A831*_B
    111 Enzyme Activity:
    PP1[8]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*845*_B845*
    		A845*_B845*
    112 Enzyme Activity:
    PP1[9]

    Enzyme Molecule:
    PP1-active_PSD    		2.000050.354explicit E-S complexA831*_B845*
    		A_B845*
    113 Enzyme Activity:
    PP2A-dephosph-I1

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexI1*
    		I1
      PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    114 Enzyme Activity:

    PP2A-dephosph-I1
    _
    PSD

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexI1*
    		I1
      PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    115 Enzyme Activity:
    PP2A-dephosph-PP
    1-I*

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexPP1-I1*
    		PP1-I1
      k1 changed from 3.3e-6 to 6.6e-6
    116 Enzyme Activity:

    PP2A-dephosph-PP
    1-I*_
    PSD

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexPP1-I1*
    		PP1-I1
      k1 changed from 3.3e-6 to 6.6e-6
    117 Enzyme Activity:
    PP2B

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B845*
    		A_B845*
    118 Enzyme Activity:
    PP2B[10]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA_B831*845*
    		A_B831*
    119 Enzyme Activity:
    PP2B[11]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B831*
    		A_B831*
    120 Enzyme Activity:
    PP2B[12]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*_B831*845*
    121 Enzyme Activity:
    PP2B[13]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*845*_B831*
    122 Enzyme Activity:
    PP2B[14]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B831*
    		A831*_B831*
    123 Enzyme Activity:
    PP2B[15]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*_B831*845*
    		A831*_B831*
    124 Enzyme Activity:
    PP2B[17]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B
    		A_B
    125 Enzyme Activity:
    PP2B[18]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B
    		A831*_B
    126 Enzyme Activity:
    PP2B[19]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B831*
    		A_B831*
    127 Enzyme Activity:
    PP2B[1]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B845*
    		A845*_B
    128 Enzyme Activity:
    PP2B[20]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B831*
    		A831*_B831*
    129 Enzyme Activity:
    PP2B[21]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA_B845*
    		A_B
    130 Enzyme Activity:
    PP2B[22]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*_B845*
    		A831*_B
    131 Enzyme Activity:
    PP2B[23]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA_B831*845*
    		A_B831*
    132 Enzyme Activity:
    PP2B[24]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*_B831*845*
    		A831*_B831*
    133 Enzyme Activity:
    PP2B[25]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B845*
    		A_B845*
    134 Enzyme Activity:
    PP2B[26]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B845*
    		A831*_B845*
    135 Enzyme Activity:
    PP2B[27]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B831*845*
    		A_B831*845*
    136 Enzyme Activity:
    PP2B[28]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*_B831*845*
    137 Enzyme Activity:
    PP2B[29]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B845*
    		A845*_B
    138 Enzyme Activity:
    PP2B[2]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA_B845*
    		A_B
    139 Enzyme Activity:
    PP2B[30]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B845*
    		A831*845*_B
    140 Enzyme Activity:
    PP2B[31]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B831*845*
    		A845*_B831*
    141 Enzyme Activity:
    PP2B[32]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complex
  • A835*845*_
    B835*845*
    		• A831*845*_B831*
    142 Enzyme Activity:
    PP2B[3]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B
    		A_B
    143 Enzyme Activity:
    PP2B[4]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B845*
    		A831*_B845*
    144 Enzyme Activity:
    PP2B[5]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B845*
    		A831*845*_B
    145 Enzyme Activity:
    PP2B[6]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*_B845*
    		A831*_B
    146 Enzyme Activity:
    PP2B[7]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA831*845*_B
    		A831*_B
    147 Enzyme Activity:
    PP2B[8]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B831*845*
    		A_B831*845*
    148 Enzyme Activity:
    PP2B[9]

    Enzyme Molecule:
    CaM_Ca_n-CaNAB    		4.9706124explicit E-S complexA845*_B831*845*
    		A845*_B831*


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