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Reaction List for pathway IP4-system (Pathway Number 129) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
5kinase | 0.0132
(s^-1) | 0
(uM^-1 s^-1) | - | - | IP3-56Kcmplx
| IP4(1345)
IP3-56K
| | | Kf = 0.274 times Vmax of IP3 56-K as product ratio of Ins(1345)P4 : Ins(1346)P4 is 1 : 2.3-5 from Wilson and Majerus, JBC 271; 1996 | | 2 |
6kinase | 0.048
(s^-1) | 0
(uM^-1 s^-1) | - | - | IP3-56Kcmplx
| IP4(1346)
IP3-56K
| | | Kf = Vmax for IP3 56K from Wilson and Majerus, JBC 271; 1996 | | 3 |
ip3-inhib-1k | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | IP4-1K
IP3(134)
| IP3-1Kcmplx
| | | from Tan et al, JBC 272; 1997 | | 4 |
IP3-Kcmplx-on | 3
(uM^-1 s^-1) | 0.192
(s^-1) | Kd(bf) = 0.064(uM) | - | IP3(134)
IP3-56K
| IP3-56Kcmplx
| | | Kf and Kb are equivalent to k1 and k2 for InsP3 56-K, calculated from Km and Vmax values provided by Wilson and Majerus, JBC 271; 1996 | | 5 |
ip4-5K | 0.008
(s^-1) | 0
(s^-1) | - | - | IP4(1346)
| IP5(13456)
| | | rate based on basal levels of Ins(1346)P4 | | 6 |
ip4-6pase | 0.01
(s^-1) | 0
(s^-1) | - | - | IP4(1456)
| IP3(145)
| | | this step is essential to maintain flux around the network, rate adjusted accordingly | | 7 |
ip4-inhib-56k | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | IP4(3456)
IP3-56Kcmplx
| IP4(3456)-56k-cm
plx
| | | from Hughes et al, JBC 264(33); 1989: 19871-78 | | 8 |
ip4-inhib-56k[1] | 1
(uM^-1 s^-1) | 6.3
(s^-1) | Kd(bf) = 6.3(uM) | - | IP3-56Kcmplx
IP4(1345)
| IP4(1345)-56k-cm
plx
| | | from Shears, JBC 264(33); 1989: 19879-86 | | 9 |
ip5-1-pase | 0.0031
(s^-1) | 0
(s^-1) | - | - | IP5(13456)
| IP4(3456)
| | | most probable reaction for Ins(3456)P4 synthesis as per Yang et al, JBC 274(27); 1999: 18973-80 | | 10 |
ip5-inhib-1k | 1
(uM^-1 s^-1) | 15
(s^-1) | Kd(bf) = 15(uM) | - | IP4-1K
IP5(13456)
| IP5-1Kcmplx
| | | from Tan et al, JBC 272; 1997 | | 11 |
ip5_3pase | 0.0005
(s^-1) | 0
(s^-1) | - | - | IP5(13456)
| IP4(1456)
| | | Ins(13456)P5 3-phosphatase from Nogimori et al, JBC 266; 1991 |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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