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Reaction List for pathway CaMKII (Pathway Number 174) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | Autonomous-bind- CaMCa4 | 33.2998 (uM^-1 s^-1) | 0 (s^-1) | - | - | CaMCa4 Autonomous | Trapped-T286 |
| 2 | Autonomous_ lose_CaMCa4 | 0.02 (s^-1) | 0 (uM^-1 s^-1) | - | - | Trapped-T286 | Autonomous CaMCa4 |
| Holmes says that this rate is variable, and depends on Ca conc. It is 0.1 when [Ca] = 10 nM, and 0.00355/sec when [Ca] is 1.0 For our purposes, we assume a good steady approx to this rate is 0.02. | |||||||
| 3 | CaMKII-bind-CaM | 0.2 (uM^-1 s^-1) | 2700 (s^-1) | Kd(bf) = 13500(uM) | - | CaM CaMKII | CaMKII-CaM |
| 4 | CaMKII-bind-CaMC a | 0.8 (uM^-1 s^-1) | 2700 (s^-1) | Kd(bf) = 3375.0084(uM) | - | CaMCa CaMKII | CAMKII-CaMCa |
| 5 | CaMKII-bind-CaMC a2 | 2 (uM^-1 s^-1) | 2250 (s^-1) | Kd(bf) = 1125(uM) | - | CaMCa2 CaMKII | CaMKII-CaMCa2 |
| 6 | CaMKII-bind-CaMC a3 | 100.004 (uM^-1 s^-1) | 22.5 (s^-1) | Kd(bf) = 0.225(uM) | - | CaMCa3 CaMKII | CaMKII-CaMCa3 |
| 7 | CaMKII-bind-CaMC a4 | 100.004 (uM^-1 s^-1) | 4.5 (s^-1) | Kd(bf) = 0.045(uM) | - | CaMCa4 CaMKII | CaMKII-CaMCa4 |
| 8 | CaMKII-CaM-bind- Ca | 4 (uM^-1 s^-1) | 20 (s^-1) | Kd(bf) = 5(uM) | - | CaMKII-CaM Ca | CAMKII-CaMCa |
| 9 | CaMKII-CaMCa-bin d-Ca | 100.004 (uM^-1 s^-1) | 20 (s^-1) | Kd(bf) = 0.2(uM) | - | CAMKII-CaMCa Ca | CaMKII-CaMCa2 |
| 10 | CaMKII-CaMCa2-bi nd-Ca | 100.004 (uM^-1 s^-1) | 2 (s^-1) | Kd(bf) = 0.02(uM) | - | CaMKII-CaMCa2 Ca | CaMKII-CaMCa3 |
| 11 | CaMKII-CaMCa3-bi nd-Ca | 100.004 (uM^-1 s^-1) | 100 (s^-1) | Kd(bf) = 1(uM) | - | CaMKII-CaMCa3 Ca | CaMKII-CaMCa4 |
| 12 | dephosph_T286 | 0.003 (s^-1) | 0 (s^-1) | - | - | Autonomous | CaMKII |
| 13 | dephosph_T305 | 0.01 (s^-1) | 0 (s^-1) | - | - | Capped | Autonomous |
| This is treated as a separate reaction because it is independent of the CaMKII concentration or activation state, unlike the forward reaction in the Holmes paper. Holmes tries a range of rates for this step, and says it doesn't matter much. | |||||||
| 14 | Dephosph_ trapped_T286 | 0.003 (s^-1) | 0 (s^-1) | - | - | Trapped-T286 | CaMKII-CaMCa4 |
| This rate is for the back reaction for the step represented here as a separate enzyme, but by Holmes as a single reversible reaction. Here it is treated as separate because the forward reaction is dependent on activity levels of the CaMKII, whereas the back reaction is not. Holmes tries a range of values for this back-reaction and says that it doesn't matter much. | |||||||
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