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Accession Type:
Network

fig2_egfr

Shared_Object_
fig2_egfr

		PKC
		Molecule
		Reaction

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Reaction List for pathway PKC (Pathway Number 2)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.

	Name	Kf	Kb	Kd	tau	Substrate	Product
1	PKC-act-by-AA	0.0001 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 833.3333(uM)	-	AA PKC-cytosolic	PKC-AA*
2	PKC-act-by-Ca	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	PKC-cytosolic Ca	PKC-Ca
3	PKC-act-by-Ca-AA	0.0012 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 83.3333(uM)	-	PKC-Ca AA	PKC-Ca-AA*
4	PKC-act-by-DAG	0.008 (uM^-1 s^-1)	8.6348 (s^-1)	Kd(bf) = 1079.377(uM)	-	DAG PKC-Ca	PKC-Ca-DAG
5	PKC-act-by-DAG-A A	2 (s^-1)	0.2 (s^-1)	Keq = 0.1(uM)	0.455sec	PKC-DAG-AA	PKC-DAG-AA*
6	PKC-basal-act	1 (s^-1)	50 (s^-1)	Keq = 50(uM)	0.02sec	PKC-cytosolic	PKC-basal*
7	PKC-Ca-to-memb	1.2705 (s^-1)	3.5026 (s^-1)	Keq = 2.7569(uM)	0.21sec	PKC-Ca	PKC-Ca-memb*
8	PKC-DAG-to-memb	1 (s^-1)	0.1 (s^-1)	Keq = 0.1(uM)	0.909sec	PKC-Ca-DAG	PKC-DAG-memb*
9	PKC-n-DAG	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6667(uM)	-	PKC-cytosolic DAG	PKC-DAG
10	PKC-n-DAG-AA	0.018 (uM^-1 s^-1)	2 (s^-1)	Kd(bf) = 111.1111(uM)	-	PKC-DAG AA	PKC-DAG-AA

Pathway Details Molecule List Enzyme List Reaction List

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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