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Accession Type:
Network
fig2_egfr
Shared_Object_
fig2_egfr
PKC
PLA2
PLCbeta
 Molecule
 Enzyme
 Reaction
Gq
MAPK
Ras
EGFR
Sos
PLC_g
CaRegulation

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Reaction List for pathway PLCbeta (Pathway Number 4)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 Act-PLC-by-Gq25.2
(uM^-1 s^-1)		1
(s^-1)		Kd(bf) = 0.0397(uM)-G*GTP
PLC-Ca
PLC-Ca-Gq
2 Act-PLC-Ca3
(uM^-1 s^-1)		1
(s^-1)		Kd(bf) = 0.3333(uM)-Ca
PLC
PLC-Ca
3 Degrade-DAG0.15
(s^-1)		0
(s^-1)		Not applicable**-DAG
PC
4 Degrade-IP32.5
(s^-1)		0
(s^-1)		--IP3
Inositol
5 Inact-PLC-Gq0.0133
(s^-1)		0
(uM^-1 s^-1)		--PLC-Ca-Gq
G*GDP
PLC-Ca
6 PLC-bind-Gq2.52
(uM^-1 s^-1)		1
(s^-1)		Kd(bf) = 0.3968(uM)-PLC
G*GTP
PLC-Gq
7 PLC-Gq-bind-Ca30
(uM^-1 s^-1)		1
(s^-1)		Kd(bf) = 0.0333(uM)-Ca
PLC-Gq
PLC-Ca-Gq


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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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