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Accession Type:
Network
NonOsc_Ca_
IP3metabolism
MIPP
CaMKII
CaM
PKC
 Molecule
 Enzyme
 Reaction
IP3-3K
CaRegulation
Gq
PLCbeta
134_dephos
145_dephos
IP4-system
IHP-system
1345_dephos

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Parameters for PKC (Pathway Number 147)

Pathway Layout

Pathway Basic Parameters

Pathway NamePKC
Pathway Entry Number 147
Accession Number 31
Accession Name NonOsc_Ca_IP3metabolism
Species Generic mammalian
Tissue Brain - Neuronal
CellCompartmentCytosol
Related Pathways 2, 20, 34, 55, 60, 71, 108, 123, 138, 161, 181, 200, 207, 313, 330, 348, 364, 370, 376, 383, 389, 395, 401, 408, 414, 420, 426, 431, 437, 443, 449, 455, 461, 467, 473, 479, 485, 491, 497, 503, 509, 515, 521, 527, 534, 540, 546, 552, 558, 564, 570, 576, 582, 588, 594, 600, 606, 612, 618, 624, 630, 636, 642, 648, 654, 660, 666, 672, 678, 685, 691, 698, 703, 709, 715, 721, 727, 733, 739, 745, 751, 757, 763, 769, 775, 781, 787, 793, 799, 805, 811, 817, 823, 829, 835, 841, 847, 853, 859, 865, 871, 877, 883, 889, 895, 901, 907, 913, 919, 927, 932, 938, 944, 950, 956, 963, 969, 974, 981, 987, 993, 999, 1004, 1010, 1016, 1022, 1028, 1034, 1040, 1046, 1052, 1058, 1064, 1104
Notes Protein Kinase C. This module represents a weighted average of the alpha, beta and gamma isoforms. It takes inputs from Ca, DAG (Diacyl Glycerol) and AA (arachidonic acid). Regulation parameters are largely from Schaechter and Benowitz 1993 J Neurosci 13(10):4361 who use synaptosomes from mammalian brain and in one paper look at all three inputs. Shinomura et al 1991 PNAS 88:5149-5153 is also a useful source of data and helps to tighten the DAG inputs. General reviews include Azzi et al 1992 Eur J Bioch 208:541 and Nishizuka 1988, Nature 334:661 Concentration info from Kikkawa et al 1982 JBC 257(22):13341 The process of parameterization is described in detail in several places. See Supplementary notes to Bhalla and Iyengar 1999 Science 284:92-96, available at the site http://www.ncbs.res.in/~bhalla/ltploop/pkc_example.html The parameterization is also described in a book chapter: Bhalla, 2000: Simulations of Biochemical Signaling in Computational Neuroscience: Realistic Modeling for Experimentalists. Ed. E. De Schutter. CRC Press.

Statistics

13
1
10

Conversion format

This pathway is part of accession 31 and is completely specified in the file acc31.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc31.g   
GENESIS Format (Annotated version)    Anno_acc31.g   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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