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Molecule Parameter List for E4*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
E4* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1021100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • MAPK_Asthagiri_
    adapt_fb
  • 45Pathway
    MAPK 
    This is a complex model to examine mechanisms that govern MAPK pathway dynamics in Chinese hamster ovary (CHO) cell lines, particularly the role of adapter targeted negative feedback mechanism in generating complete signal adaptation. This model simulates the results as per the figure 7A of the paper by Asthagiri AR and Lauffenburger DA. Biotechnol Prog. (2001) 17(2):227-39.

    E4* acting as a Molecule in  
    MAPK_Asthagiri_adapt_fb Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    E4*
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0390No
    Active form of enzyme from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    E4* acting as an Enzyme in  
    MAPK_Asthagiri_adapt_fb Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1E4* /
    E5_activ
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.06000010.15explicit E-S complexSubstrate
    E5

    Product
    E5*
        k5+ =6*10^8 M-1 min-1, k5- =30 min-1, kcat,5 =6 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39
    2E4* /
    E4*_adpt_fb
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.06000010.15explicit E-S complexSubstrate
    E0*

    Product
    A2-
        Implementation of adapter feedback induces adaptation of not only the target signal e0* but also signals downstream of the target. k5+ =6*10^8 M-1 min-1, k5- =30 min-1, kcat,5 =6 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    E4* acting as a Substrate for an Enzyme in  
    MAPK_Asthagiri_adapt_fb Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    P4  /
    E4*_deactiv
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.06000010.15explicit E-S complexSubstrate
    E4*

    Product
    E4
    kp4+ = 6*10^8 M-1 min-1, kp4- =30 min-1, kpcat,4 =6 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39

    E4* acting as a Product of an Enzyme in  
    MAPK_Asthagiri_adapt_fb Network
    Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    E3*  /
    E4_activ
  • MAPK_Asthagiri_
    adapt_fb

    Accession No. : 45
  • MAPK
    Pathway No. : 193
    0.06000010.15explicit E-S complexSubstrate
    E4

    Product
    E4*
    k4+ = 6*10^8 M-1 min-1, k4- =30 min-1, kcat,4 =6 min-1 from Anand R. Asthagiri and Douglas A. Lauffenburger (2001 Mar-Apr) Biotechnol Prog. 17(2):227-39



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