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Molecule Parameter List for PKA-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKA-active participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences10350012

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_traff_
    model0
  • 59Network
    Shared_Object_AMPAR_traff_model0 CaMKII CaM 
    PP1 PP2B PP1_PSD 
    PKA AC AMPAR 
    AMPAR_memb 
    This is model 0 from Hayer and Bhalla, PLoS Comput Biol 2005. It has a bistable model of AMPAR traffick, plus a non-bistable model of CaMKII. This differs from the reference model (model 1) in that model0 lacks degradation and turno ver reactions for AMPAR.

    PKA-active acting as a Molecule in  
    AMPAR_traff_model0 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PKA-active
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    00.09No

    PKA-active acting as an Enzyme in  
    AMPAR_traff_model0 Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PKA-active /
    phosph-PDE
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5000894explicit E-S complexSubstrate
    cAMP-PDE

    Product
    cAMP-PDE*
        Same rates as PKA-phosph-I1
    2PKA-active /
    PKA-phosph-I1
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5000894explicit E-S complexSubstrate
    I1

    Product
    I1*
        #s from Bramson et al CRC crit rev Biochem 15:2 93-124. They have a huge list of peptide substrates and I have chosen high-ish rates. These consts give too much PKA activity, so lower Vmax 1/3. Now, k1 = 3e-5, k2 = 36, k3 = 9 (still pretty fast). Also lower Km 1/3 so k1 = 1e-5 Cohen et al FEBS Lett 76:182-86 1977 say rate =30% PKA act on phosphokinase beta.
    3PKA-active /
  • PKA-phosph-I1_
    PSD
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5000894explicit E-S complexSubstrate
    I1

    Product
    I1*
    4PKA-active /
    PKA[17]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A845*_B
    5PKA-active /
    PKA[16]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B

    Product
    A831*845*_B
    6PKA-active /
    PKA[18]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B831*

    Product
    A845*_B831*
    7PKA-active /
    PKA[19]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B831*

    Product
    A831*845*_B831*
    8PKA-active /
    PKA[20]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A_B845*
    9PKA-active /
    PKA[21]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B

    Product
    A831*_B845*
    10PKA-active /
    PKA[22]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B831*

    Product
    A_B831*845*
    11PKA-active /
    PKA[23]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B831*

    Product
    A831*_B831*845*
    12PKA-active /
    PKA[24]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B845*

    Product
    A845*_B845*
    13PKA-active /
    PKA[25]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B845*

    Product
    A831*845*_B845*
    14PKA-active /
    PKA[26]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B831*845*

    Product
    A845*_B831*845*
    15PKA-active /
    PKA[27]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B831*845*

    Product
  • A835*845*_
    B835*845*

  • 16PKA-active /
    PKA[28]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A845*_B

    Product
    A845*_B845*
    17PKA-active /
    PKA[29]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*845*_B

    Product
    A831*845*_B845*
    18PKA-active /
    PKA[30]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A845*_B831*

    Product
    A845*_B831*845*
    19PKA-active /
    PKA[31]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*845*_B831*

    Product
  • A835*845*_
    B835*845*

  • 20PKA-active /
    PKA
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B845*

    Product
    A845*_B845*
    21PKA-active /
    PKA[1]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A845*_B

    Product
    A845*_B845*
    22PKA-active /
    PKA[2]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A845*_B
    23PKA-active /
    PKA[3]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B

    Product
    A_B845*
    24PKA-active /
    PKA[4]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B845*

    Product
    A831*845*_B845*
    25PKA-active /
    PKA[5]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*845*_B

    Product
    A831*845*_B845*
    26PKA-active /
    PKA[6]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B

    Product
    A831*_B845*
    27PKA-active /
    PKA[7]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B

    Product
    A831*845*_B
    28PKA-active /
    PKA[8]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B831*845*

    Product
    A845*_B831*845*
    29PKA-active /
    PKA[9]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A845*_B831*

    Product
    A845*_B831*845*
    30PKA-active /
    PKA[10]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B831*

    Product
    A_B831*845*
    31PKA-active /
    PKA[11]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A_B831*

    Product
    A845*_B831*
    32PKA-active /
    PKA[12]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B831*845*

    Product
  • A835*845*_
    B835*845*

  • 33PKA-active /
    PKA[13]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*845*_B831*

    Product
  • A835*845*_
    B835*845*

  • 34PKA-active /
    PKA[14]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B831*

    Product
    A831*_B831*845*
    35PKA-active /
    PKA[15]
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    7.5002164explicit E-S complexSubstrate
    A831*_B831*

    Product
    A831*845*_B831*

    PKA-active acting as a Substrate in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    inhib-PKA
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    59.9994
    (uM^-1 s^-1)
    1
    (s^-1)
    Kd(bf) = 0.0167(uM)-Substrate
    PKA-active
    PKA-inhibitor

    Product
    inhibited-PKA
    This has to be set to zero for matching the expts in vitro. In vivo we need to consider the inhibition though. kf = 1e-5 kb = 1

    PKA-active acting as a Product in a reaction in  
    AMPAR_traff_model0 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Release-C1
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    60
    (s^-1)
    17.9998
    (uM^-1 s^-1)
    Kd(cb) = 0.3(uM)-Substrate
    R2C2-cAMP4

    Product
    PKA-active
    R2C-cAMP4
      This has to be fast, as the activation of PKA by cAMP is also fast. kf was 10
    2Release-C2
  • AMPAR_traff_
    model0

    Accession No. : 59
  • PKA
    Pathway No. : 240
    60
    (s^-1)
    17.9998
    (uM^-1 s^-1)
    Kd(cb) = 0.3(uM)-Substrate
    R2C-cAMP4

    Product
    PKA-active
    R2-cAMP4



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