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Molecule Parameter List for tot_autonomous_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
tot_autonomous_CaMKII participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1220000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    weak_coupling
    		• 65Network
    Shared_Object_AMPAR_CaMKII_weak_coupling,  CaMKII,  CaM,  
    PP1,  PP2B,  PP1_PSD,  
    AMPAR,  PKA,  AC,  
    AMPAR_memb,  PP1_CaMKII_PSD,  CaMKII_PSD 
    This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

    tot_autonomous_CaMKII acting as a Molecule in      AMPAR_CaMKII_weak_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    tot_autonomous_CaMKII
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII
    Pathway No. : 282    		20.09No

    tot_autonomous_CaMKII acting as a Summed Molecule in      AMPAR_CaMKII_weak_coupling Network
     Accession NanePathway NameTargetInput
    1
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII
    Pathway No. : 282    		tot_autonomous_CaMKIICaMKII-thr286
    CaMKII***
  • basal_CaMKII_
    cyt
    • 2
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII
    Pathway No. : 282    		act_CaMKII_cyttot_CaM_CaMKII
  • tot_autonomous_
    CaMKII

    • tot_autonomous_CaMKII acting as an Enzyme in      AMPAR_CaMKII_weak_coupling Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1
  • tot_autonomous_
    CaMKII     /
    auton_305
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII
    Pathway No. : 282    		35064explicit E-S complexSubstrate
    CaMKII-thr286

    Product
    CaMKII***
        See Hanson and Schulman again, for afterburst rates of phosph.
    2
  • tot_autonomous_
    CaMKII     /
    auton_286
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII
    Pathway No. : 282    		349.9870.54explicit E-S complexSubstrate
    CaMKII-CaM

    Product
  • CaMKII-thr286*-C
    aM


    • Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.