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Molecule Parameter List for inact-GEF | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2007_ReacDiff3 | 84 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff3, PKC, PLA2,
MAPK, PLA2, Ras, CaM, chain, kinetics, PKC, MAPK, Ras, CaM, kinetics[1],
PKC, PLA2, MAPK, Ras, CaM, kinetics[2], PKC, PLA2, MAPK, Ras, CaM, kinetics[3],
PKC, PLA2, MAPK, Ras, CaM, kinetics[4], PKC, PLA2, MAPK, Ras, CaM, kinetics[5],
PKC, PLA2, MAPK, Ras, MAPK, CaM, kinetics[6], PKC, PLA2, MAPK, Ras,
CaM, kinetics[7], PKC, PLA2, MAPK, Ras, CaM, PKC, kinetics[8], PLA2,
MAPK, Ras, CaM, kinetics[9], PKC, PLA2, MAPK, Ras, CaM, kinetics[10],
PKC, PLA2, MAPK, Ras, CaM, kinetics[11], PKC, PLA2, MAPK, Ras, CaM,
kinetics[12], PKC, PLA2, Ras, CaM, kinetics[13], PKC, PLA2, MAPK,
Ras, CaM, kinetics[14], PKC, PLA2, MAPK, Ras, CaM, kinetics[15],
PKC, PLA2, MAPK, Ras, kinetics[16], CaM, PKC, PLA2, MAPK, Ras, CaM,
kinetics[17], PKC, PLA2, MAPK, Ras, CaM, kinetics[18], PKC, PLA2,
MAPK, Ras, CaM, kinetics[19], PKC, PLA2, MAPK, Ras, CaM, kinetics[20],
PKC, PLA2, MAPK, Ras, CaM, kinetics[21], PKC, PLA2, MAPK, Ras, CaM,
kinetics[22], PKC, PLA2, MAPK, Ras, CaM, kinetics[23], PKC, PLA2,
MAPK, Ras, CaM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. |
inact-GEF acting as a Molecule in Ajay_Bhalla_2007_ReacDiff3 Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 923 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 929 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 935 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 941 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 947 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 953 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 959 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 966 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 972 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 978 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 984 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 990 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 996 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1001 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1007 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1013 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1019 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1025 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1031 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1037 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1043 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1049 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1055 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1061 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. | | inact-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1067 | 0.1 | 125.7 | No | | Assume that SoS is present only at 50 nM. Revised to 100 nM to get equil to experimentally known levels. |
inact-GEF acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff3 Network
inact-GEF acting as a Substrate for an Enzyme in Ajay_Bhalla_2007_ReacDiff3 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 2 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics
Pathway No. : 926 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 3 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[1]
Pathway No. : 931 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 4 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[2]
Pathway No. : 937 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 5 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[3]
Pathway No. : 943 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 6 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[4]
Pathway No. : 949 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 7 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[5]
Pathway No. : 955 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 8 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[6]
Pathway No. : 962 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 9 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[7]
Pathway No. : 968 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 10 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[8]
Pathway No. : 975 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 11 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[9]
Pathway No. : 980 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 12 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[10]
Pathway No. : 986 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 13 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[11]
Pathway No. : 992 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 14 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[12]
Pathway No. : 998 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 15 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[13]
Pathway No. : 1003 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 16 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[14]
Pathway No. : 1009 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 17 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[15]
Pathway No. : 1015 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 18 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[16]
Pathway No. : 1020 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 19 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[17]
Pathway No. : 1027 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 20 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[18]
Pathway No. : 1033 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 21 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[19]
Pathway No. : 1039 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 22 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[20]
Pathway No. : 1045 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 23 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[21]
Pathway No. : 1051 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 24 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[22]
Pathway No. : 1057 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X | | 25 | PKC-active /
PKC-act-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[23]
Pathway No. : 1063 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
inact-GEF
Product
GEF*
| | | Rate consts from PKC-act-raf. This reaction activates GEF. It can lead to at least 2X stim of ras, and a 2X stim of MAPK over and above that obtained via direct phosph of c-raf. Note that it is a push-pull reaction, and there is also a contribution through the phosphorylation and inactivation of GAPs. The original PKC-act-raf rate consts are too fast. We lower K1 by 10 X |
inact-GEF acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 2 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 923 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 3 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 4 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 929 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 5 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 6 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 935 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 7 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 959 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 8 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 9 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 941 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 10 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 11 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 947 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 12 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 13 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 953 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 14 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 15 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 16 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 966 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 17 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 18 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 972 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 19 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 20 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 978 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 21 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 22 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 984 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 23 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 24 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 990 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 25 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 26 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 996 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 27 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 28 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1001 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 29 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 30 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1007 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 31 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 32 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1013 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 33 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 34 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1019 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 35 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 36 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1025 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 37 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 38 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1031 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 39 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 40 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1037 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 41 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 42 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1043 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 43 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 44 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1049 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 45 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 46 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1055 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 47 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
inact-GEF
Product
inact-GEF
| | 48 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1061 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | | 49 | CaM-bind-GEF | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Ras
Pathway No. : 1067 | 199.995
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.005(uM) | - | Substrate
CaM-Ca4
inact-GEF
Product
CaM-GEF
| | | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. |
inact-GEF acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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