Enter a Search String |
| Special character and space not allowed in the query term. Search string should be at least 2 characters long. |
Molecule List for pathway MAPK (Pathway Number 139) in Accession MAPK_osc (Accession Number 27) |
Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.  arrow indicates that ordering is done according to ascending or descending order.The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| Name | Accession Type | Initial Conc. (uM) | Volume (fL) | Buffered | Sum Total Of | |||
| 1 | | Pathway | 0 | 0.0016667 | No | - | ||
| This is the inactive form of Ras-MKKK. Based on the reaction scheme from Kholodenko 2000, this is equivalent to a binding of the MAPK-PP to the Ras. The amount of Ras in the model is small enough that negligible amounts of MAPK are involved in this reaction. So it is a fair approximation to the negative feedback mechanism from Kholodenko, 2000. | ||||||||
| 2 | int1 | Pathway | 0.001 | 0.0016667 | No | - | ||
| This is the intermediate enzyme which catalyses the dephosphorylation of MKKK-P to MKKK. The concentration is set to 1 nM based on from Kholodenko, 2000 | ||||||||
| 3 | int2 | Pathway | 0.001 | 0.0016667 | No | - | ||
| This intermediate enzyme which catalyses the dephosphorylation of MKK-PP to MKK-P. The concentration is 1nM. from Kholodenko, 2000 | ||||||||
| 4 | int3 | Pathway | 0.001 | 0.0016667 | No | - | ||
| This intermediate enzyme catalyses the dephosphorylation of MKK-P to MKK. The concentration is 1nM from Kholodenko, 2000 | ||||||||
| 5 | int4 | Pathway | 0.001 | 0.0016667 | No | - | ||
| This intermediate enzyme catalyses the dephosphorylation of MAPK-PP to MAPK-P. The concentration is 1nM. from Kholodenko, 2000 | ||||||||
| 6 | int5 | Pathway | 0.001 | 0.0016667 | No | - | ||
| This catalyses the conversion of MAPK-P to MAPK. The concenration is 1nM. from Kholodenko, 2000 | ||||||||
| 7 | MAPK | Pathway | 0.3 | 0.0016667 | No | - | ||
| The total concn. of MAPK is 300nM from Kholodenko, 2000. | ||||||||
| 8 | MAPK-P | Pathway | 0 | 0.0016667 | No | - | ||
| This is the single phopshorylated form of MAPK from Kholodenko, 2000. | ||||||||
| 9 | MAPK-PP | Pathway | 0 | 0.0016667 | No | - | ||
| This is the double phosphorylated and active form of MAPK. from Kholodenko, 2000. | ||||||||
| 10 | MKK | Pathway | 0.3 | 0.0016667 | No | - | ||
| The total concn. of MKK is 300nM from Kholodenko,2000 | ||||||||
| 11 | MKK-P | Pathway | 0 | 0.0016667 | No | - | ||
| This is the single phoshorylated form of MKK. from Kholodenko, 2000. | ||||||||
| 12 | MKK-PP | Pathway | 0 | 0.0016667 | No | - | ||
| This is the double phosphorylated and active form of MKK from Kholodenko, 2000 | ||||||||
| 13 | MKKK | Pathway | 0.1 | 0.0016667 | No | - | ||
| The total concn. of MKKK is 100nM from Kholodenko, 2000 | ||||||||
| 14 | MKKK-P | Pathway | 0 | 0.0016667 | No | - | ||
| This is the phosphorylated form of MKKK which converts MKK to MKK-P and then to MKK-PP from Kholodenko, 2000. | ||||||||
| 15 | Ras-MKKKK | Pathway | 0.001 | 0.0016667 | No | - | ||
| The concn. of Ras-MKKKK* is set to 1 nM implicitly from Kholodenko, 2000 | ||||||||