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Accession Type:
Network
AMPAR_CaMKII_
weak_coupling
Shared_Object_
AMPAR_CaMKII_
weak_coupling
 Molecule
 Enzyme
 Reaction
CaMKII
CaM
PP1
PP2B
PP1_PSD
AMPAR
PKA
AC
AMPAR_memb
PP1_CaMKII_PSDPP1_CaMKII_PSD
CaMKII_PSD

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Enzyme List for pathway Shared_Object_AMPAR_CaMKII_weak_coupling (Pathway Number 281)

 Molecule Name/
Site Name 		Km (uM) kcat (1/s)Ratio
(k2/k3)		Enzyme TypeSubstrate Product
1 Enzyme Activity:
Deph-thr286

Enzyme Molecule:
PP1-active		5.099052.54explicit E-S complex
  • CaMKII-thr286*-C
    aM
    		• CaMKII-CaM
    2 Enzyme Activity:
    Deph-thr286b

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMKII-thr286
    		CaMKII
    3 Enzyme Activity:
    Deph-thr286c

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMKII***
    		CaMK-thr305
    4 Enzyme Activity:
    Deph-thr305

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMKII***
    		CaMKII-thr286
    5 Enzyme Activity:
    Deph-thr305a

    Enzyme Molecule:
    PP1-active    		5.099052.54explicit E-S complexCaMK-thr305
    		CaMKII
    6 Enzyme Activity:
    phosph-AC2

    Enzyme Molecule:
    PKC-active    		33.333744explicit E-S complexAC2
    		AC2*
      Phorbol esters have little effect on AC1 or on the Gs-stimulation of AC2. So in this model we are only dealing with the increase in basal activation of AC2 induced by PKC k1 = 1.66e-6 k2 = 16 k3 =4
    7 Enzyme Activity:
    PKC-phosph-neuro
    granin

    Enzyme Molecule:
    PKC-active    		28.62730.584.03448explicit E-S complexneurogranin
    		neurogranin*
      Rates from Huang et al ABB 305:2 570-580 1993
    8 Enzyme Activity:

    PKC-phosph-neuro
    granin_
    PSD

    Enzyme Molecule:
    PKC-active    		28.62730.584.03448explicit E-S complexneurogranin_PSD
  • neurogranin*_
    PSD
    •   Rates from Huang et al ABB 305:2 570-580 1993
    9 Enzyme Activity:
    PKC-phosph-ng-Ca
    M

    Enzyme Molecule:
    PKC-active    		28.59560.354explicit E-S complexneurogranin-CaM
    		CaM
    neurogranin*
      Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
    10 Enzyme Activity:

    PKC-phosph-ng-Ca
    M_
    PSD

    Enzyme Molecule:
    PKC-active    		28.59560.354explicit E-S complex

  • neurogranin-CaM_
    PSD
    		• CaM-PSD
  • neurogranin*_
    PSD
    •   Rates are 60% those of PKC-phosph-neurogranin. See Huang et al ABB 305:2 570-580 1993
    11 Enzyme Activity:
    PP2A-dephosph-I1

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexI1*
    		I1
      PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    12 Enzyme Activity:

    PP2A-dephosph-I1
    _
    PSD

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexI1*
    		I1
      PP2A does most of the dephosph of I1 at basal Ca levels. See the review by Cohen in Ann Rev Biochem 1989. For now, lets halve Km. k1 was 3.3e-6, now 6.6e-6
    13 Enzyme Activity:
    PP2A-dephosph-PP
    1-I*

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexPP1-I1*
    		PP1-I1
      k1 changed from 3.3e-6 to 6.6e-6
    14 Enzyme Activity:

    PP2A-dephosph-PP
    1-I*_
    PSD

    Enzyme Molecule:
    PP2A    		15.999924.1667explicit E-S complexPP1-I1*
    		PP1-I1
      k1 changed from 3.3e-6 to 6.6e-6


    Pathway Details   Molecule List  Enzyme List   Reaction List  

    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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