 |  |  IHP-system |
|  |  Molecule |
| | Enzyme |
| | Reaction |
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Reaction List for pathway IHP-system (Pathway Number 116) | | Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| | Name | Kf | Kb | Kd | tau | Substrate | Product | | 1 |
dipp_ip6 | kf
(s^-1) | 0
(s^-1) | - | - | PP-IP4
| IP5(13456)
| | | rate based on basal levels of PP-InsP4 | | 2 |
IP5-dipp-inhib | kf
(uM^-1 s^-1) | 1.6
(s^-1) | Kd(bf) = 1.6(uM) | - | DIPP1
IP5(13456)
| IP5-DIPPcmplx
| | | IC50=1.6uM from Safrany et al, EMBO J 17(22); 1998 | | 3 |
ip5-kinase-pase | kf
(s^-1) | 1.92
(s^-1) | Keq = 1.92(uM) | 0.342sec | IP5(13456)
| IP6
| | | Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels | | 4 |
IP6-dipp-inhib | kf
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | IP6
DIPP1
| IP6-DIPPcmplx
| | | IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998 | | 5 |
IP6cmplx-off | kf
(s^-1) | 0.0012
(uM^-2 s^-1) | - | - | IP6-K-complex
| PP-IP5
ADP
IP6-K
| | | from Voglmaier et al, PNAS 93; 1996 Kf = Vmax of forward reaction Kb calculated from Km for InsP6 and ATP, and Vmax of forward and backward reactions | | 6 |
IP6cmplx-on | kf
(uM^-2 s^-1) | 2.376
(s^-1) | - | - | IP6
ATP
IP6-K
| IP6-K-complex
| | | from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction | | 7 |
PP-IP5cmplx-off | kf
(s^-1) | 0.0013
(uM^-2 s^-1) | - | - | PP-IP5-K-complex
| ADP
bisPP-IP4
PP-IP5-K
| | | from Huang et al, Biochem 37; 1998 Kf = Vmax of forward reaction Kb calculated using Km for PP-InsP5 and ATP, and Vmax of forward and backward reactions | | 8 |
PP-IP5cmplx-on | kf
(uM^-2 s^-1) | 2.5
(s^-1) | - | - | ATP
PP-IP5
PP-IP5-K
| PP-IP5-K-complex
| | | from Huang et al, Biochem 37; 1998 Kf calculated using Km for PP-InsP5 and ATP, and Vmax of forward and backward reactions. Kb = Vmax of backward reaction |
Pathway Details Molecule List Enzyme List Reaction List
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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